Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications

Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications Publisher Pubmed

Eivazzadehkeihan R¹ ; Alimirzaloo F¹ ; Aghamirza Moghim Aliabadi H^{2, 3} ; Bahojb Noruzi E⁴ ; Akbarzadeh AR⁵ ; Maleki A¹ ; Madanchi H^{6, 7} ; Mahdavi M⁸

Show Affiliations

1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
2. Protein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
3. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
4. Department of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
5. Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
6. Department of Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
7. Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
8. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Scientific Reports Published:2022

Abstract

In this paper, a novel graphene oxide-folic acid/silk fibroin (GO-FA/SF) nanobiocomposite scaffold was designed and fabricated using affordable and non-toxic materials. The GO was synthesized using the hummer method, covalently functionalized with FA, and then easily conjugated with extracted SF via the freeze-drying process. For characterization of the scaffold, several techniques were employed: Fourier-transform infrared (FT-IR), field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), and thermogravimetric analysis (TGA). The cell viability method, hemolysis, and anti-biofilm assays were performed, exploring the biological capability of the nanobiocomposite. The cell viability percentages were 96.67, 96.35 and 97.23% for 24, 48, and 72 h, respectively, and its hemolytic effect was less than 10%. In addition, it was shown that this nanobiocomposite prevents the formation of Pseudomonas aeruginosa biofilm and has antibacterial activity. © 2022, The Author(s).

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Mohammad Mahdavi (26)

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Style	Citing Format
MLA	Eivazzadehkeihan R, et al.. "Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications." Scientific Reports, vol. 12, no. 1, 2022, pp. -.
APA	Eivazzadehkeihan R, Alimirzaloo F, Aghamirza Moghim Aliabadi H, Bahojb Noruzi E, Akbarzadeh AR, Maleki A, Madanchi H, Mahdavi M (2022). Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications. Scientific Reports, 12(1), -.
Chicago	Eivazzadehkeihan R, Alimirzaloo F, Aghamirza Moghim Aliabadi H, Bahojb Noruzi E, Akbarzadeh AR, Maleki A, Madanchi H, Mahdavi M. "Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications." Scientific Reports 12, no. 1 (2022): -.
Harvard	Eivazzadehkeihan R et al. (2022) 'Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications', Scientific Reports, 12(1), pp. -.
Vancouver	Eivazzadehkeihan R, Alimirzaloo F, Aghamirza Moghim Aliabadi H, Bahojb Noruzi E, Akbarzadeh AR, Maleki A, et al.. Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications. Scientific Reports. 2022;12(1):-.
BibTex	@article{ author = {Eivazzadehkeihan R and Alimirzaloo F and Aghamirza Moghim Aliabadi H and Bahojb Noruzi E and Akbarzadeh AR and Maleki A and Madanchi H and Mahdavi M}, title = {Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications}, journal = {Scientific Reports}, volume = {12}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Eivazzadehkeihan R AU - Alimirzaloo F AU - Aghamirza Moghim Aliabadi H AU - Bahojb Noruzi E AU - Akbarzadeh AR AU - Maleki A AU - Madanchi H AU - Mahdavi M TI - Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications JO - Scientific Reports VL - 12 IS - 1 SP - EP - PY - 2022 ER -

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