The Interplay Between Gut Microbiota Composition and Dementia Publisher

Summary: Gut bugs and brain fog? Review ties microbiota like Akkermansia muciniphila to dementia via metabolites (SCFAs, LPS). Probiotics may slow progression. Tummy tune-up for mind? #GutMicrobiome #Dementia

Ghannadzadeh Kermani Pour R⁵ ; Kamali Zounouzi S⁵ ; Farshbafnadi M^{2, 5} ; Rezaei N^{1, 2, 3, 4}
Source: Reviews in the Neurosciences Published:2025

Abstract

Recently, researchers have been interested in the potential connection between gut microbiota composition and various neuropsychological disorders. Dementia significantly affects the socioeconomics of families. Gut microbiota is considered as a probable factor in its pathogenesis. Multiple bacterial metabolites such as short-chain fatty acids, lipopolysaccharides, and various neurotransmitters that are responsible for the incidence and progression of dementia can be produced by gut microbiota. Various bacterial species such as Bifidobacterium breve, Akkermansia muciniphila, Streptococcus thermophilus, Escherichia coli, Blautia hydrogenotrophica, etc. are implicated in the pathogenesis of dementia. Gut microbiota can be a great target for imitating or inhibiting their metabolites as an adjunctive therapy based on their role in its pathogenesis. Therefore, some diets can prevent or decelerate dementia by altering the gut microbiota composition. Moreover, probiotics can modulate gut microbiota composition by increasing beneficial bacteria and reducing detrimental species. These therapeutic modalities are considered novel methods that are probably safe and effective. They can enhance the efficacy of traditional medications and improve cognitive function. © 2025 Walter de Gruyter GmbH, Berlin/Boston.