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Topical Spray of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord Accelerates Diabetic Wound Healing Publisher Pubmed



Nilforoushzadeh MA1, 2 ; Afzali H3 ; Raoofi A4 ; Nouri M1 ; Naser R5 ; Gholami O4 ; Nasiry D6 ; Mohammadnia A7, 8 ; Razzaghi Z9 ; Alimohammadi A10 ; Naraghi ZS11 ; Peyrovan A1 ; Jahangiri F1 ; Khodaverdi Darian E12, 13 Show All Authors
Authors
  1. Nilforoushzadeh MA1, 2
  2. Afzali H3
  3. Raoofi A4
  4. Nouri M1
  5. Naser R5
  6. Gholami O4
  7. Nasiry D6
  8. Mohammadnia A7, 8
  9. Razzaghi Z9
  10. Alimohammadi A10
  11. Naraghi ZS11
  12. Peyrovan A1
  13. Jahangiri F1
  14. Khodaverdi Darian E12, 13
  15. Rustamzadeh A14
  16. Zare S1, 9

Source: Journal of Cosmetic Dermatology Published:2022


Abstract

Background and Aim: Cell-based therapy utilizing mesenchymal stem cells (MSCs) is currently being investigated as a therapeutic agent for chronic wounds. There is no evidence regarding effectiveness of the spray and local transfer of this cellular product in diabetic wound healing. Accordingly, the present study, using clinical, pathological and biometric parameters, investigated the effectiveness of the spray of these cells in the healing of diabetic wounds in rats. Methods: Three days after the induction of diabetes (50 mg/kg single dose of streptozotocin) a circular excision was created on the back of rats. Diabetic rats were divided into two groups (n = 21): Control and WJ-MSCs group. Sampling of the studied groups was performed on Days 7, 14, and 21 after wounding. Histological, ultrasound imaging of dermis and epidermis in the wound area for thickness and density measurement and skin elasticity were evaluated. Results: Our results on Days 7, 14, and 21 after wounding showed that the wound closure, thickness, and density of new epidermis and dermis, as well as skin elasticity in healed wound were significantly higher in WJ-MSCs group compared with the Control group. Conclusion: Application of WJ-MSCs suspension spray on the wound area can accelerate healing in diabetic wounds. Our findings may potentially provide a helpful therapeutic strategy for patients with a diabetic wound. © 2022 Wiley Periodicals LLC.
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