Unveiling Therapeutic Potential: Adipose Tissue-Derived Mesenchymal Stem Cells and Their Exosomes in the Management of Diabetes Mellitus, Wound Healing, and Chronic Ulcers Publisher Pubmed



Ahmadiehyazdi A¹ ; Karimi M¹ ; Afkhami E^{1, 2} ; Hajizadehtafti F¹ ; Kuchakzadeh F^{1, 3} ; Yang P⁴ ; Sheykhhasan M⁵ Show Affiliations
Source: Biochemical Pharmacology Published:2024

Abstract

Diabetes mellitus (DM) is a pervasive global health issue with substantial morbidity and mortality, often resulting in secondary complications, including diabetic wounds (DWs). These wounds, arising from hyperglycemia, diabetic neuropathy, anemia, and ischemia, afflict approximately 15% of diabetic patients, with a considerable 25% at risk of lower limb amputations. The conventional approaches for chronic and diabetic wounds management involves utilizing various therapeutic substances and techniques, encompassing growth factors, skin substitutes and wound dressings. In parallel, emerging cell therapy approaches, notably involving adipose tissue-derived mesenchymal stem cells (ADMSCs), have demonstrated significant promise in addressing diabetes mellitus and its complications. ADMSCs play a pivotal role in wound repair, and their derived exosomes have garnered attention for their therapeutic potential. This review aimed to unravel the potential mechanisms and provide an updated overview of the role of ADMSCs and their exosomes in diabetes mellitus and its associated complications, with a specific focus on wound healing. © 2024 Elsevier Inc.