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Effect of Melatonin Supplementation on Cardiometabolic Risk Factors, Oxidative Stress and Hormonal Profile in Pcos Patients: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Ziaei S1 ; Hasani M2 ; Malekahmadi M3 ; Daneshzad E4 ; Kadkhodazadeh K5 ; Heshmati J6
Authors
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Authors Affiliations
  1. 1. ICU Department, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Nutritional Sciences, School of Health, Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. Imam Khomeini Hospital Complex, Tehran University of Medicinal Sciences, Tehran, Iran
  4. 4. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. University of Ottawa Heart Institute, Ottawa, Canada

Source: Journal of Ovarian Research Published:2024


Abstract

Background: To investigate whether melatonin supplementation can enhance cardiometabolic risk factors, reduce oxidative stress, and improve hormonal and pregnancy-related factors in patients with PCOS. Methods: We conducted a systematic search of PubMed/Medline, Scopus, and the Cochrane Library for articles published in English from inception to March 2023. We included randomized controlled trials (RCTs) on the use of melatonin for patients with polycystic ovary syndrome (PCOS). We performed a meta-analysis using a random-effects model and calculated the standardized mean differences (SMDs) and 95% confidence intervals (CIs). Results: Six studies met the inclusion criteria. The result of meta-analysis indicated that melatonin intake significantly increase TAC levels (SMD: 0.87, 95% CI: 0.46, 1.28, I2 = 00.00%) and has no effect on FBS, insulin, HOMA-IR, TC, TG, HDL, LDL, MDA, hs-CRP, mFG, SHBG, total testosterone, and pregnancy rate in patients with PCOS compare to controls. The included trials did not report any adverse events. Conclusion: Melatonin is a potential antioxidant that may prevent damage from oxidative stress in patients with PCOS. However, the clear effect of melatonin supplementation on cardiometabolic risk factors, hormonal outcomes, and pregnancy-related outcomes needs to be evaluated further in large populations and long-term RCTs. © The Author(s) 2024.
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