Radio Protective Effect of Black Mulberry Extract on Radiation-Induced Damage in Bone Marrow Cells and Liver in the Rat

Radio Protective Effect of Black Mulberry Extract on Radiation-Induced Damage in Bone Marrow Cells and Liver in the Rat Publisher

Ghasemnezhad Targhi R¹ ; Homayoun M² ; Mansouri S² ; Soukhtanloo M^{3, 4} ; Soleymanifard S⁵ ; Seghatoleslam M^{2, 6}

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1. Department of Radiology, Faculty of Allied, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3. Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4. Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5. Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6. Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Radiation Physics and Chemistry Published:2017

Abstract

Ionizing radiation by producing free radicals induces tissue oxidative stress and has clastogenic and cytotoxic effects. The radio protective effect of black mulberry extract (BME) has been investigated on liver tissue and bone marrow cells in the rat. Intraperitoneal (ip) administration of 200 mg/kg BME three days before and three days after 3 Gy and 6 Gy gamma irradiation significantly reduced the frequencies of micro nucleated polychromatic erythrocytes (MnPCEs) and micro nucleated norm chromatic erythrocyte (MnNCEs) and increased PCE/PCE+NCE ratio in rat bone marrow compared to the non-treated irradiated groups. Moreover, this concentration of BME extract decreased the level of malondialdehyde (MDA) and superoxide dismutase (SOD), as well as enhanced the total thiol content and catalase activity in rat's liver compared to the non-treated irradiated groups. It seems that BME extract with antioxidant activity reduced the genotoxicity and cytotoxicity induced by gamma irradiation in bone marrow cells and liver in the rat. © 2016 Elsevier Ltd

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Style	Citing Format
MLA	Ghasemnezhad Targhi R, et al.. "Radio Protective Effect of Black Mulberry Extract on Radiation-Induced Damage in Bone Marrow Cells and Liver in the Rat." Radiation Physics and Chemistry, vol. 130, no. , 2017, pp. 297-302.
APA	Ghasemnezhad Targhi R, Homayoun M, Mansouri S, Soukhtanloo M, Soleymanifard S, Seghatoleslam M (2017). Radio Protective Effect of Black Mulberry Extract on Radiation-Induced Damage in Bone Marrow Cells and Liver in the Rat. Radiation Physics and Chemistry, 130(), 297-302.
Chicago	Ghasemnezhad Targhi R, Homayoun M, Mansouri S, Soukhtanloo M, Soleymanifard S, Seghatoleslam M. "Radio Protective Effect of Black Mulberry Extract on Radiation-Induced Damage in Bone Marrow Cells and Liver in the Rat." Radiation Physics and Chemistry 130, no. (2017): 297-302.
Harvard	Ghasemnezhad Targhi R et al. (2017) 'Radio Protective Effect of Black Mulberry Extract on Radiation-Induced Damage in Bone Marrow Cells and Liver in the Rat', Radiation Physics and Chemistry, 130(), pp. 297-302.
Vancouver	Ghasemnezhad Targhi R, Homayoun M, Mansouri S, Soukhtanloo M, Soleymanifard S, Seghatoleslam M. Radio Protective Effect of Black Mulberry Extract on Radiation-Induced Damage in Bone Marrow Cells and Liver in the Rat. Radiation Physics and Chemistry. 2017;130():297-302.
BibTex	@article{ author = {Ghasemnezhad Targhi R and Homayoun M and Mansouri S and Soukhtanloo M and Soleymanifard S and Seghatoleslam M}, title = {Radio Protective Effect of Black Mulberry Extract on Radiation-Induced Damage in Bone Marrow Cells and Liver in the Rat}, journal = {Radiation Physics and Chemistry}, volume = {130}, number = {}, pages = {297-302}, year = {2017} }
RIS	TY - JOUR AU - Ghasemnezhad Targhi R AU - Homayoun M AU - Mansouri S AU - Soukhtanloo M AU - Soleymanifard S AU - Seghatoleslam M TI - Radio Protective Effect of Black Mulberry Extract on Radiation-Induced Damage in Bone Marrow Cells and Liver in the Rat JO - Radiation Physics and Chemistry VL - 130 IS - SP - 297 EP - 302 PY - 2017 ER -

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