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Histologic Evaluation of the Bone Regeneration Capacities of Bio-Oss and Mineross X in Rabbit Calvarial Defects Publisher Pubmed



Esfahanizadeh N4 ; Daneshparvar P1 ; Takzaree N2 ; Rezvan M4 ; Daneshparvar N3
Authors
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Authors Affiliations
  1. 1. School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Anatomy and Histology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Periodontics, Indiana University, School of Dentistry, Indianapolis, IN, United States
  4. 4. Department of Periodontics, Dental Branch, Islamic Azad University, Unit 7, Flr 4, No. 4, Mohensi Alley, Rastvan St, Tehran, Darous, 1946615314, Iran

Source: International Journal of Periodontics and Restorative Dentistry Published:2019


Abstract

Several methods are used for periodontal regeneration and alveolar ridge reconstruction. This study aimed to compare the bone regeneration capacities of MinerOss X, Bio-Oss, and autograft in rabbit calvaria. In this animal study, four defects measuring 8 mm in diameter were created in the calvaria of 10 rabbits using a trephine bur. Three defects were randomly filled with MinerOss X, Bio-Oss, and autogenous bone. The fourth defect remained empty as a control. The rabbits were sacrificed after 4 or 8 weeks. Calvarial samples were taken and histopathologically evaluated. The mean number of osteoblasts and the amount of newly formed bone in all groups were higher at 8 compared to 4 weeks. At 4 and 8 weeks, the amount of newly formed bone and number of osteoblasts and osteocytes in MinerOss X group were significantly greater than the corresponding values in other groups, and MinerOss X was superior to Bio-Oss and autograft in all the assessed variables at both 4 and 8 weeks (P < .001). Within the limitations of this study, the results showed that the number of osteoblasts and osteocytes and the amount of newly formed bone in the MinerOss X group were higher than those in Bio-Oss and autograft groups. However, further clinical studies are warranted. © 2019 by Quintessence Publishing Co Inc.
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