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The Recent Advancement in the Chitosan-Based Thermosensitive Hydrogel for Tissue Regeneration Publisher



Abdollahi A1 ; Malekkhatabi A1 ; Razavi MS2, 3 ; Sheikhi M4 ; Abbaspour K5 ; Rezagholi Z6 ; Atashi A6 ; Rahimzadegan M7 ; Sadeghi M8 ; Javar HA8
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  2. 2. Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, 111554563, Iran
  6. 6. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Journal of Drug Delivery Science and Technology Published:2023


Abstract

To date, hydrogel-based scaffolds have opened new prospects for potential applications for drug delivery and regeneration. The novel delivery strategies such as thermo-sensitive hydrogels can improve their performance via the controllable release of therapeutic/bioactive agents in response to changes in temperature. Chitosan (CS) is a natural safe copolymer with good biocompatibility and biodegradability. Recently, chitosan-based formulations have attracted a lot of interest for thermo-sensitive injectable hydrogels. Thermo-sensitive chitosan-based hydrogels provide the proper manner for the smart drug delivery and tissue engineering. This review is focused to the recent progression of the various thermo-sensitive and biodegradable chitosan-based hydrogels that have been developed for different tissue (bone, cartilage, nucleus pulposus, cardiac, and wound) engineering and smart drug/cell delivery. Subsequently, future perspectives and challenges of thermo-sensitive CS-based hydrogels are discussed briefly. © 2023
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