A Comprehensive Review of the Relationship Between Air Pollution and Type 2 Diabetes Publisher



S Dehghani SAMANEH ; V Oskoei VAHIDE ; Nb Yazdi Niloofar BORHANI ; Ss Yousefabad Samira SHEIKHY ; A Jafarian ARIAN ; M Rezvani Ghalhari MOHAMMAD ; S Abolli SAMANEH
Source: Published:2024

Abstract

Air pollution, a significant contributor to worldwide disease, is associated with various noncommunicable ailments such as diabetes, chronic obstructive pulmonary diseases, and asthma. Strong epidemiological evidence has revealed that there is an association between environmental pollution and diabetes prevalence and boosted morbidity and mortality among diabetic patients. Ambient air pollutant exposure is said to exert its effects via elevated systemic inflammation, oxidative stress, and mitochondrial dysfunction, all contributing to type 2 diabetes. Recent research has indicated that direct contact with airborne particulate matter from pollution can lead to adverse effects on endothelial function, increased systemic inflammation, and the occurrence of endoplasmic reticulum stress. This chapter primarily focuses on the connection between air pollution and the prevalence and mortality rates associated with diabetes, the boosted susceptibility of diabetic individuals to ambient air pollution, the correlations between exposure to outdoor air pollution and the development of type 2 diabetes, potential mechanisms by which air pollution contributes to the onset or worsening of diabetes, and the impact of air pollution exposure on risk factors related to diabetes. © 2024 Elsevier B.V., All rights reserved.