Tehran University of Medical Sciences

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Quality of Life After Botulinum Toxin Injection in Patients With Adductor Spasmodic Dysphonia; a Systematic Review and Meta-Analysis Publisher Pubmed



Faham M1, 2 ; Ahmadi A3 ; Silverman E4 ; Harouni GG5 ; Dabirmoghaddam P6
Authors
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Authors Affiliations
  1. 1. Department of Speech and Language Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Rehabilitation Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Speech Therapy, School of Rehabilitation, Babol University of Medical Sciences, Babol, IR, Iran
  4. 4. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, United States
  5. 5. Social Welfare Management Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  6. 6. Otolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Voice Published:2021


Abstract

Introduction: Adductor spasmodic dysphonia is an extremely disabling voice disorder that negatively impacts a patient's quality of life (QOL). We performed a systematic review to determine if Botulinum Toxin (BT) injections improved voice related QOL in patients with this disorder. Methods: PubMed, EMBASE, Web of Science, Cochrane Library, ProQuest, and Scopus from 2000, to and including November 1st, 2018, were searched. We identified randomized controlled trials, controlled trials, and observational studies of the effects of BT injections on the QOL in patients with adductor spasmodic dysphonia. The two authors, separately and individually chose the studies based on inclusion criteria, assessed study quality, and relevant extracted data. Results: Nine studies used the Voice Handicap Index (VHI). The results showed significant changes pre- to post-BT injection (SMD = −0.357; 95% CI: −0.579, −0.136; z = 3.16; P = 0.002; I-squared = 0.000%). Five studies used the Voice-Related QOL; their results also showed a significant improvement pre- to postinjection (SMD = −2.99; 95% CI: −3.27, −1.32; z = 4.61; P < 0.001; I-squared = 87%). Three other studies used other, shortened versions of the VHI, VHI-10. They also showed significant results (SMD = −0.145; 95% CI: −0.349, 0.06; z = 1.38; P = 0.17; I-squared = 0.000). Conclusion: BT injections positively affect patients’ QOL. However, patients’ QOL scores may never be normalized, in line with perceptual voice quality and acoustic parameters. © 2019 The Voice Foundation
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