Association of Ace I/D, -240A > T and At1r A1166c Polymorphisms With Susceptibility to Breast Cancer: A Systematic Review and Meta-Analysis Based on 35 Case-Control Studies Publisher Pubmed



Dastgheib SA¹ ; Asadian F² ; Farbod M³ ; Karimizarchi M^{4, 5} ; Meibodi B^{6, 10} ; Akbarian E⁷ ; Neamatzadeh H^{8, 9} Show Affiliations
Source: Nucleosides# Nucleotides and Nucleic Acids Published:2020

Abstract

The objective of this meta-analysis was to estimate the association of ACE I/D, −240 A > T and AT1R 1166 A > C polymorphisms with breast cancer (BC) risk. A comprehensive search on databases was conducted to identify all eligible case-control studies. Finally, 35 case-control studies, including 20 studies for ACE I/D, seven studies for ACE 240 A > T, and eight studies for AT1R 1166 A > C were included. The pooled analysis showed a significant association between ACE I/D polymorphism and BC risk under three genetic models, i.e., heterozygote (ID vs. DD: OR = 0.707, 95% CI 0.528-0.946, p = 0.020), homozygote (II vs. DD: OR = 0.662, 95% CI 0.462-0.947, p = 0.024), and dominant (II + ID vs. DD: OR = 0.691, 95% CI 0.507-0.941, p = 0.019). A significant association was also observed in ACE I/D polymorphism with BC risk among Asians and Caucasians. However, ACE −240 A > T and AT1R 1166 A > C polymorphisms were not associated with BC. Stratified analyses by ethnicity showed a significant association of ACE −240 A > T and AT1R 1166 A > C polymorphisms with BC risk in Latinos populations, but not in Asians. This meta-analysis inconsistence with all previous meta-analyses suggests that the ACE I/D might be associated with BC in overall and by ethnicity. However, the ACE −240 A > T and AT1R 1166 A > C were associated with BC risk only among Latinos populations. © 2020 Taylor & Francis Group, LLC.