Factors Associated With Mortality in Covid-19 Patients: A Systematic Review and Meta-Analysis Publisher



Sepandi M^{1, 2} ; Taghdir M¹ ; Alimohamadi Y^{3, 4} ; Afrashteh S^{5, 6} ; Hosamirudsari H⁷
Source: Iranian Journal of Public Health Published:2020

Abstract

Background: The current study aimed to identify effective factors on the death among COVID-19 patients. Methods: All articles published in the period Jan 1, 2020, to Mar 23, 2020, written in English and reporting fac-tors associated with COVID-19 mortality were reviewed. The random-effects model with 95% CI was used to calculate the pooled Odds Ratio (OR) and Hazard Ratio (HR). Data were analyzed using Stata ver.11.0. Results: The older age OR: 1.21(1.10-1.33) and male gender OR: 1.41(1.04-1.89) were most prone to death due to COVID-19. The Comorbidity with some chronic diseases such as Diabetes type2 OR: 2.42(1.06-5.52), Hy-pertension OR: 2.54(1.21-5.32), Kidney disorder OR: 2.61(1.22-5.60), Respiratory disorder 3.09 (1.39-6.88) and Heart diseases OR: 4.37 (1.13-16.90) can increase the risk of COVID19 mortality. Conclusion: Infection with COVID-19 is associated with substantial mortality mainly in older patients with comorbidities. We found the significant effect of age, gender and comorbidities such as Diabetes Mellitus, Hy-pertension, Kidney disorders and Heart diseases on the risk of death in patients with COVID-19. The factors associated with mortality found in this research can help to recognize patients with COVID-19 who are at high-er risk of a poor prognosis. Monitoring these factors can serve to give early warning for the appropriate inter-ventions. © 2020, Iranian Journal of Public Health. All rights reserved.