Ph-Sensitive Bilayer Electrospun Nanofibers Based on Ethyl Cellulose and Eudragit S-100 As a Dual Delivery System for Treatment of the Burn Wounds; Preparation, Characterizations, and In-Vitro/In-Vivo Assessment

Ph-Sensitive Bilayer Electrospun Nanofibers Based on Ethyl Cellulose and Eudragit S-100 As a Dual Delivery System for Treatment of the Burn Wounds; Preparation, Characterizations, and In-Vitro/In-Vivo Assessment Publisher Pubmed

Amani M^{1, 2} ; Rakhshani A¹ ; Maghsoudian S^{1, 2} ; Rasoulzadehzali M³ ; Yoosefi S⁴ ; Keihankhadiv S⁵ ; Fatahi Y^{1, 2, 6} ; Darbasizadeh B⁷ ; Ebrahimi SM⁸ ; Ejarestaghi NM⁹ ; Farhadnejad H⁷ ; Motasadizadeh H^{1, 2}

Show Affiliations

1. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran university of Medical Sciences, Tehran, Iran
2. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Laboratory of Dendrimers and Nano-Biopolymers, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
4. Department of Drug and Food Control, Faculty of pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, Gliwice, 44-100, Poland
6. Universal Scientific Education and Research Network (USERN), Tehran, Iran
7. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8. Medical Plants Research Center, Institute of Medical Plants, ACECR, Karaj, Iran
9. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2023

Abstract

A pH-sensitive bilayer electrospun nanofibrous mat containing both antibiotic (gentamicin sulfate, GEN) and non-steroidal anti-inflammatory (diclofenac sodium, DIC) drugs was fabricated for burn wound dressing by electrospinning technique, in which ethyl cellulose (EC) and ethyl cellulose/Eudragit S-100 (EC/ES-100) formed the top and bottom layers, respectively. The fabricated pH-sensitive bilayer electrospun nanofibrous mats were characterized from aspects of both structure and efficiency. Physicochemical properties were investigated via SEM, FTIR, and TGA. The swelling ratio and in vitro drug release of the fabricated nanofibrous mats were studied in different pHs. MTT was applied to assess the safety of the fiber mats. Finally, the in vivo efficiency of the designed pH-sensitive bilayer electrospun nanofibrous mats was examined on the male Wistar rats. Based on the histological analysis and wound healing test (in vivo animal experiments), the (ES100/EC-DIC/GEN)-(EC) pH-sensitive bilayer nanofibrous mat displayed faster wound healing than other bilayer nanofibrous mat. As a result, (ES100/EC-DIC/GEN)-(EC) bilayer nanofibrous mat with pH-responsion could accelerate the burn wound healing process via decreasing the adverse effects of GEN and DIC as topical antimicrobial and anti-inflammatory agents, receptively. © 2023

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Rassoul Dinarvand (4)

Mohammad Akrami (1)

Style	Citing Format
MLA	Amani M, et al.. "Ph-Sensitive Bilayer Electrospun Nanofibers Based on Ethyl Cellulose and Eudragit S-100 As a Dual Delivery System for Treatment of the Burn Wounds; Preparation, Characterizations, and In-Vitro/In-Vivo Assessment." International Journal of Biological Macromolecules, vol. 249, no. , 2023, pp. -.
APA	Amani M, Rakhshani A, Maghsoudian S, Rasoulzadehzali M, Yoosefi S, Keihankhadiv S, Fatahi Y, Darbasizadeh B, Ebrahimi SM, Ejarestaghi NM, Farhadnejad H, Motasadizadeh H (2023). Ph-Sensitive Bilayer Electrospun Nanofibers Based on Ethyl Cellulose and Eudragit S-100 As a Dual Delivery System for Treatment of the Burn Wounds; Preparation, Characterizations, and In-Vitro/In-Vivo Assessment. International Journal of Biological Macromolecules, 249(), -.
Chicago	Amani M, Rakhshani A, Maghsoudian S, Rasoulzadehzali M, Yoosefi S, Keihankhadiv S, Fatahi Y, et al.. "Ph-Sensitive Bilayer Electrospun Nanofibers Based on Ethyl Cellulose and Eudragit S-100 As a Dual Delivery System for Treatment of the Burn Wounds; Preparation, Characterizations, and In-Vitro/In-Vivo Assessment." International Journal of Biological Macromolecules 249, no. (2023): -.
Harvard	Amani M et al. (2023) 'Ph-Sensitive Bilayer Electrospun Nanofibers Based on Ethyl Cellulose and Eudragit S-100 As a Dual Delivery System for Treatment of the Burn Wounds; Preparation, Characterizations, and In-Vitro/In-Vivo Assessment', International Journal of Biological Macromolecules, 249(), pp. -.
Vancouver	Amani M, Rakhshani A, Maghsoudian S, Rasoulzadehzali M, Yoosefi S, Keihankhadiv S, et al.. Ph-Sensitive Bilayer Electrospun Nanofibers Based on Ethyl Cellulose and Eudragit S-100 As a Dual Delivery System for Treatment of the Burn Wounds; Preparation, Characterizations, and In-Vitro/In-Vivo Assessment. International Journal of Biological Macromolecules. 2023;249():-.
BibTex	@article{ author = {Amani M and Rakhshani A and Maghsoudian S and Rasoulzadehzali M and Yoosefi S and Keihankhadiv S and Fatahi Y and Darbasizadeh B and Ebrahimi SM and Ejarestaghi NM and Farhadnejad H and Motasadizadeh H}, title = {Ph-Sensitive Bilayer Electrospun Nanofibers Based on Ethyl Cellulose and Eudragit S-100 As a Dual Delivery System for Treatment of the Burn Wounds; Preparation, Characterizations, and In-Vitro/In-Vivo Assessment}, journal = {International Journal of Biological Macromolecules}, volume = {249}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Amani M AU - Rakhshani A AU - Maghsoudian S AU - Rasoulzadehzali M AU - Yoosefi S AU - Keihankhadiv S AU - Fatahi Y AU - Darbasizadeh B AU - Ebrahimi SM AU - Ejarestaghi NM AU - Farhadnejad H AU - Motasadizadeh H TI - Ph-Sensitive Bilayer Electrospun Nanofibers Based on Ethyl Cellulose and Eudragit S-100 As a Dual Delivery System for Treatment of the Burn Wounds; Preparation, Characterizations, and In-Vitro/In-Vivo Assessment JO - International Journal of Biological Macromolecules VL - 249 IS - SP - EP - PY - 2023 ER -

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