Phage Therapy As an Approach to Control Salmonella Enterica Serotype Enteritidis Infection in Mice

Phage Therapy As an Approach to Control Salmonella Enterica Serotype Enteritidis Infection in Mice Publisher Pubmed

Dallal MMS^{1, 2} ; Nikkhahi F^{3, 4} ; Alimohammadi M⁵ ; Douraghi M^{2, 3} ; Rajabi Z² ; Foroushani AR⁶ ; Azimi A^{3, 4} ; Fardsanei F³

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1. Division of Food Microbiology, Department of Pathobiology, School of Public Health (TUMS), Tehran, Iran
2. Food Microbiology Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran
3. Division of Medical Bacteriology, Department of Pathobiology, School of Public Health (TUMS), Tehran, Iran
4. Medical Microbiology Research Center, Qazvin University of Medical Science, Qazvin, Iran
5. Environmental Health Engineering Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Revista da Sociedade Brasileira de Medicina Tropical Published:2019

Abstract

Introduction: Salmonella enterica serotype Enteritidis (S. Enteritidis) is a cause of food-borne human illness. Given the prevalence of antibiotic resistance of Salmonella Enteritidis and the lack of antibiotic efficacy in future years, its replacement with other agents is necessary. One of the most useful agents is bacteriophages. Methods: S. Enteritidis was identified using a multiplex polymerase chain reaction assay. The effective bacteriophages were isolated from hospital wastewater samples. The effects of the bacteriophages were evaluated both in vitro and in vivo. Results: The phage SE20 belonged to the Podoviridae family, and the genome size was 40 kb. The evaluation of phage SE20 at variable pH ranges showed its susceptibility to pH < 3 and pH > 12. The animal model showed that mice infected with S. Enteritidis developed hepatomegaly and splenomegaly, but did not experience gastrointestinal complications after receiving the bacteriophages. Conclusions: The results of this study suggest that phage SE20 is a promising candidate for controlling salmonellosis caused by Salmonella Enteritidis. © 2019, Sociedade Brasileira de Medicina Tropical. All rights reserved.

Style	Citing Format
MLA	Dallal MMS, et al.. "Phage Therapy As an Approach to Control Salmonella Enterica Serotype Enteritidis Infection in Mice." Revista da Sociedade Brasileira de Medicina Tropical, vol. 52, no. , 2019, pp. -.
APA	Dallal MMS, Nikkhahi F, Alimohammadi M, Douraghi M, Rajabi Z, Foroushani AR, Azimi A, Fardsanei F (2019). Phage Therapy As an Approach to Control Salmonella Enterica Serotype Enteritidis Infection in Mice. Revista da Sociedade Brasileira de Medicina Tropical, 52(), -.
Chicago	Dallal MMS, Nikkhahi F, Alimohammadi M, Douraghi M, Rajabi Z, Foroushani AR, Azimi A, Fardsanei F. "Phage Therapy As an Approach to Control Salmonella Enterica Serotype Enteritidis Infection in Mice." Revista da Sociedade Brasileira de Medicina Tropical 52, no. (2019): -.
Harvard	Dallal MMS et al. (2019) 'Phage Therapy As an Approach to Control Salmonella Enterica Serotype Enteritidis Infection in Mice', Revista da Sociedade Brasileira de Medicina Tropical, 52(), pp. -.
Vancouver	Dallal MMS, Nikkhahi F, Alimohammadi M, Douraghi M, Rajabi Z, Foroushani AR, et al.. Phage Therapy As an Approach to Control Salmonella Enterica Serotype Enteritidis Infection in Mice. Revista da Sociedade Brasileira de Medicina Tropical. 2019;52():-.
BibTex	@article{ author = {Dallal MMS and Nikkhahi F and Alimohammadi M and Douraghi M and Rajabi Z and Foroushani AR and Azimi A and Fardsanei F}, title = {Phage Therapy As an Approach to Control Salmonella Enterica Serotype Enteritidis Infection in Mice}, journal = {Revista da Sociedade Brasileira de Medicina Tropical}, volume = {52}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Dallal MMS AU - Nikkhahi F AU - Alimohammadi M AU - Douraghi M AU - Rajabi Z AU - Foroushani AR AU - Azimi A AU - Fardsanei F TI - Phage Therapy As an Approach to Control Salmonella Enterica Serotype Enteritidis Infection in Mice JO - Revista da Sociedade Brasileira de Medicina Tropical VL - 52 IS - SP - EP - PY - 2019 ER -

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