Benefit Effect of Rem-Sleep Deprivation on Memory Impairment Induced by Intensive Exercise in Male Wistar Rats: With Respect to Hippocampal Bdnf and Trkb Publisher



Mahboubi S¹ ; Nasehi M² ; Imani A^{3, 4} ; Sadatshirazi MS^{1, 2, 3, 4, 5} ; Zarrindast MR^{5, 6, 7} ; Vousooghi N¹ ; Noroozian M^{1, 2, 3, 4, 5, 6, 7, 8} Show Affiliations
Source: Nature and Science of Sleep Published:2019

Abstract

Background: Many factors affect our learning and memory quality, but according to different studies, having a positive or negative impact pertains to their characteristics like intensity or the amount. Purpose: The present study was conducted to investigate the effect of 24-hour REM-sleep deprivation on continuous-high intensity forced exercise-induced memory impairment and its effect on Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine kinase B (TrkB) levels in the hippocampus and Prefrontal Cortex area (PFC). Material and methods: Animals were conditioned to run on treadmills for 5 weeks then, were deprived of sleep for 24 h using the modified multiple platforms. The effect of intensive exercise and/or 24-h REM-SD was studied on behavioral performance using Morris Water Maze protocol for 2 days, and BDNF/TrkB levels were assessed in hippocampus and PFC after behavioral probe test using western blotting. Results: After 5 weeks of intensive exercise and 24-h REM-SD, spatial memory impairment and reduction of BDNF and TrkB levels were found in hippocampus and PFC. 24-h REMSD improved memory impairment and intensive exercise-induced downregulation of BDNF and TrkB protein levels. Conclusion: The results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition. © 2019 Mahboubi et al.