Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Intricate Role of Sleep Deprivation in Modulating Depression: Focusing on Bdnf, Vegf, Serotonin, Cortisol, and Tnf-Α Publisher Pubmed



Vaseghi S1 ; Mostafavijabbari A2 ; Alizadeh MS3, 4 ; Ghaffarzadegan R1 ; Kholghi G5 ; Zarrindast MR6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
  2. 2. East Los Angeles College, Monterey Park, CA, United States
  3. 3. Department of Cognitive Neuroscience, Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  4. 4. Department of Cellular and Molecular Sciences, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Department of Psychology, Faculty of Human Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
  6. 6. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Metabolic Brain Disease Published:2023


Abstract

In this review article, we aimed to discuss intricate roles of SD in modulating depression in preclinical and clinical studies. Decades of research have shown the inconsistent effects of SD on depression, focusing on SD duration. However, inconsistent role of SD seems to be more complicated, and SD duration cannot be the only one factor. Regarding this issue, we chose some important factors involved in the effects of SD on cognitive functions and mood including brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), serotonin, cortisol, and tumor necrosis factor-alpha (TNF-α). It was concluded that SD has a wide-range of inconsistent effects on BDNF, VEGF, serotonin, and cortisol levels. It was noted that BDNF diurnal rhythm is significantly involved in the modulatory role of SD in depression. Furthermore, the important role of VEGF in blood–brain barrier permeability which is involved in modulating depression was discussed. It was also noted that there is a negative correlation between cortisol and BDNF that modulates depression. Eventually, it was concluded that TNF-α regulates sleep/wake cycle and is involved in the vulnerability to cognitive and behavioral impairments following SD. TNF-α also increases the permeability of the blood–brain barrier which is accompanied by depressive behavior. In sum, it was suggested that future studies should focus on these mechanisms/factors to better investigate the reasons behind intricate roles of SD in modulating depression. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Related Docs
View other Related Docs
1. Modulating Role of Serotonergic Signaling in Sleep and Memory, Pharmacological Reports (2022)
2. The Brain-Derived Neurotrophic Factor: Missing Link Between Sleep Deprivation, Insomnia, and Depression, Neurochemical Research (2020)
3. Dose-Dependent Manner of Luteolin in the Modulation of Spatial Memory With Respect to the Hippocampal Level of Hsp70 and Hsp90 in Sleep-Deprived Rats, Gene (2023)
4. Do Sleep Disturbances Have a Dual Effect on Alzheimer’S Disease?, Cellular and Molecular Neurobiology (2023)
5. Chronic Rem Sleep Deprivation Leads to Manic- and Ocd-Related Behaviors, and Decreases Hippocampal Bdnf Expression in Female Rats, Psychopharmacology (2024)
6. The Effect of Insomnia on Development of Alzheimer's Disease, Journal of Neuroinflammation (2020)
7. The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory With Respect to the Oxidative Status of Rats, Neurochemical Research (2023)
8. The Role of Neurotrophic Factors in Pathophysiology of Major Depressive Disorder, Advances in Experimental Medicine and Biology (2021)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (5)
Shahin Akhondzadeh Basti (5)
Other Related Docs
9. The Role of Sleep Deprivation in Streptozotocin-Induced Alzheimer’S Disease-Like Sporadic Dementia in Rats With Respect to the Serum Level of Oxidative and Inflammatory Markers, Experimental Brain Research (2022)
10. Benefit Effect of Rem-Sleep Deprivation on Memory Impairment Induced by Intensive Exercise in Male Wistar Rats: With Respect to Hippocampal Bdnf and Trkb, Nature and Science of Sleep (2019)
11. How Do Stupendous Cannabinoids Modulate Memory Processing Via Affecting Neurotransmitter Systems?, Neuroscience and Biobehavioral Reviews (2021)
12. Crocin (Bioactive Compound of Crocus Sativus L.) Potently Restores Rem Sleep Deprivation-Induced Manic- and Obsessive-Compulsive-Like Behaviors in Female Rats, Behavioural Pharmacology (2024)
13. Cannabinoids and Sleep-Wake Cycle: The Potential Role of Serotonin, Behavioural Brain Research (2021)
14. Electroconvulsive Therapy (Ect) and Aerobic Exercise Training (Aet) Increased Plasma Bdnf and Ameliorated Depressive Symptoms in Patients Suffering From Major Depressive Disorder, Journal of Psychiatric Research (2016)
15. Night Shift Hormone: How Does Melatonin Affect Depression?, Physiology and Behavior (2022)
16. Effects of Treadmill Exercise on Social Behavior in Rats Exposed to Thimerosal With Respect to the Hippocampal Level of Glun1, Glun2a, and Glun2b, Journal of Molecular Neuroscience (2022)
17. The Role of 5-Ht4 Serotonin Receptors in the Ca1 Hippocampal Region on Memory Acquisition Impairment Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Physiology and Behavior (2020)
18. The Role of Sleep Disturbances in Depressive-Like Behavior With Emphasis on Α-Ketoglutarate Dehydrogenase Activity in Rats., Physiology and Behavior (2020)
19. Effectiveness of Memantine on Depression-Like Behavior, Memory Deficits and Brain Mrna Levels of Bdnf and Trkb in Rats Subjected to Repeated Unpredictable Stress, Pharmacological Reports (2018)
20. The Role of Creb and Bdnf in Neurobiology and Treatment of Alzheimer's Disease, Life Sciences (2020)
21. Brain-Derived Neurotrophic Factor in Patients With Epilepsy: A Systematic Review and Meta-Analysis, Epilepsy Research (2021)
22. Plasticity After Pediatric Cochlear Implantation: Implication From Changes in Peripheral Plasma Level of Bdnf and Auditory Nerve Responses, International Journal of Pediatric Otorhinolaryngology (2018)
23. Behavioral Despair Associated With a Mouse Model of Crohn's Disease: Role of Nitric Oxide Pathway, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2016)
24. A Review of Molecular Interplay Between Neurotrophins and Mirnas in Neuropsychological Disorders, Molecular Neurobiology (2022)
25. Sex Steroids-Induced Neurogenesis in Adult Brain: A Better Look at Mechanisms and Mediators, Hormone Molecular Biology and Clinical Investigation (2021)
26. Synergistic Antidepressant Effects of Citalopram and Sb-334867 in the Rem Sleep-Deprived Mice: Possible Role of Bdnf, Pharmacology Biochemistry and Behavior (2022)
27. Effect of Co-Administration of Memantine and Sertraline on the Antidepressant-Like Activity and Brain-Derived Neurotrophic Factor (Bdnf) Levels in the Rat Brain, Brain Research Bulletin (2017)
28. Different Protocols of Rem Sleep Deprivation Led to Controversial Effects on Ocd- and Anxiety-Like Behaviors and Locomotor Activity in Fear Conditioning Male and Female Rats With Respect to Bdnf Expression Level, Pharmacology Biochemistry and Behavior (2025)
29. Comparing the Effect of Fluoxetine, Escitalopram, and Sertraline, on the Level of Bdnf and Depression in Preclinical and Clinical Studies: A Systematic Review, European Journal of Clinical Pharmacology (2024)
30. The Origins of the Dark—Hyperactivity and Negative Peer Relationships, an Objectively Lower Sleep Efficiency, and a Longer Sleep Onset Latency at Age Five Were Associated With Callous-Unemotional Traits and Low Empathy at Age 14, Journal of Clinical Medicine (2023)
31. The Endocannabinoid System and Ngf Are Involved in the Mechanism of Action of Resveratrol: A Multi-Target Nutraceutical With Therapeutic Potential in Neuropsychiatric Disorders, Psychopharmacology (2016)
32. The Effect of Gaba-B Receptors in the Basolateral Amygdala on Passive Avoidance Memory Impairment Induced by Mk-801 in Rats, Behavioural Brain Research (2021)
33. Adult Hippocampal Neurogenesis (Ahn) Controls Central Nervous System and Promotes Peripheral Nervous System Regeneration Via Physical Exercise, Biomedicine and Pharmacotherapy (2023)
34. Association Between Mediterranean Dietary Pattern With Sleep Duration, Sleep Quality and Brain Derived Neurotrophic Factor (Bdnf) in Iranian Adults, Scientific Reports (2023)
35. Different Role of Ca1 5Ht3 Serotonin Receptors on Memory Acquisition Deficit Induced Total(Tsd) and Rem Sleep Deprivation(Rsd), Archives of Iranian Medicine (2017)
36. Evidence for Anti-Inflammatory Effects of Adalimumab in Treatment of Patients With Major Depressive Disorder: A Pilot, Randomized, Controlled Trial, Clinical Neuropharmacology (2022)
37. Brain-Derived Neurotrophic Factor Levels in Autism: A Systematic Review and Meta-Analysis, Journal of Autism and Developmental Disorders (2017)
38. Neuroprotective Phosphatidylserine Liposomes Alleviate Depressive-Like Behavior Related to Stroke Through Neuroinflammation Attenuation in the Mouse Hippocampus, Psychopharmacology (2021)
39. Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved, Neurochemical Research (2022)
40. The Effect of Fish Oil on Social Interaction Memory in Total Sleep-Deprived Rats With Respect to the Hippocampal Level of Stathmin, Tfeb, Synaptophysin and Lamp-1 Proteins, Prostaglandins Leukotrienes and Essential Fatty Acids (2020)
41. Vascular Endothelial Growth Factor (Vegf) Delivery Approaches in Regenerative Medicine, Biomedicine and Pharmacotherapy (2023)
42. Sulfur Mustard-Related Ocular Complications: A Review of Proteomic Alterations and Pathways Involved, Current Pharmaceutical Design (2018)
43. Adipose Tissue-Derived Stromal Cells for Wound Healing, Advances in Experimental Medicine and Biology (2018)
44. Association Between Brain-Derived Neurotrophic Factor Levels and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis, Sleep and Breathing (2023)
45. Plant-Derived Natural Medicines for the Management of Depression: An Overview of Mechanisms of Action, Reviews in the Neurosciences (2015)
46. Effects of Probiotics As Adjunctive Therapy to Fluoxetine on Depression Severity and Serum Brain-Derived Neurotrophic Factor, Cortisol, and Adrenocorticotropic Hormone in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial, Food Science and Nutrition (2025)
47. Visual Attention and Poor Sleep Quality, Frontiers in Neuroscience (2022)
48. Neurobiology and Consequences of Social Isolation Stress in Animal Model—A Comprehensive Review, Biomedicine and Pharmacotherapy (2018)
49. Brain-Derived Neurotrophic Factor (Bdnf) As a Potential Biomarker in Brain Glioma: A Systematic Review and Meta-Analysis, Brain and Behavior (2025)
50. Effect of Alcohol on Brain-Derived Neurotrophic Factor (Bdnf) Blood Levels: A Systematic Review and Meta-Analysis, Scientific Reports (2023)