Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Improved Anticancer Properties of Stem Cells Derived Exosomes by Prolonged Release From Pcl Nanofibrous Structure Publisher Pubmed



Rezaie Z1 ; Ardeshirylajimi A2 ; Ashkezari MD1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Gene Published:2018


Abstract

Systemic chemotherapy as a routine method for the treatment of cancers has several complications. Localized chemotherapy can significantly increase the treatment efficacy and reduce side effects. Here, mesenchymal stem cells derived microvesicles (MVs) was incorporated into Polycaprolactone nanofibers and then the apoptotic behavior of MCF-7 breast cancer cells was investigated while cultured on MVs-Polycaprolactone by using SEM, MTT and apoptotic gene expression. Results demonstrated that MVs-Polycaprolactone group was shown a great apoptosis induction potential into MCF-7 cells and it can be concluded that MVs-Polycaprolactone has a great promising potential to introduce as an in-situ tumor inhibitor construct rather than chemo-drugs. © 2018 Elsevier B.V.
Related Docs
View other Related Docs
1. Antitumoral Potential of Microvesicles Extracted From Human Adipose-Derived Mesenchymal Stem Cells on Human Breast Cancer Cells, Journal of Cancer Research and Therapeutics (2019)
2. Texosome-Anchored Superantigen Triggers Apoptosis in Original Ovarian Cancer Cells, Medical Oncology (2015)
3. Texosome-Based Drug Delivery System for Cancer Therapy: From Past to Present, Cancer Biology and Medicine (2015)
4. To Be or Not to Be: Navigating the Influence of Micrornas on Cervical Cancer Cell Death, Cancer Cell International (2025)
5. Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications, Current Medicinal Chemistry (2021)
6. Synergistic Effects of Arsenic Trioxide and Radiation: Triggering the Intrinsic Pathway of Apoptosis, Iranian Biomedical Journal (2017)
7. Mesenchymal Stem Cell Exosomes: A Two-Edged Sword in Cancer Therapy, International Journal of Nanomedicine (2019)
8. Modulation of Apoptosis by Melatonin for Improving Cancer Treatment Efficiency: An Updated Review, Life Sciences (2019)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (2)
Mohsen Amin (2)
Other Related Docs
9. Cell Death Pathways and Viruses: Role of Micrornas, Molecular Therapy Nucleic Acids (2021)
10. Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function, Mitochondrion (2021)
11. Insulin Producing Cells Generation by Overexpression of Mir-375 in Adipose-Derived Mesenchymal Stem Cells From Diabetic Patients, Biologicals (2017)
12. The Role of Exosomes Contents on Genetic and Epigenetic Alterations of Recipient Cancer Cells, Iranian Journal of Basic Medical Sciences (2016)
13. Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight, International Journal of Stem Cells (2021)
14. Approach to the Triple Negative Breast Cancer in New Drugs Area, International Journal of Hematology-Oncology and Stem Cell Research (2016)
15. Recent Advancements to Engineer Mesenchymal Stem Cells and Their Extracellular Vesicles for Targeting and Destroying Tumors, Progress in Biophysics and Molecular Biology (2023)
16. A Newly Characterized Potentially Probiotic Strain, Lactobacillus Brevis Mk05, and the Toxicity Effects of Its Secretory Proteins Against Mcf-7 Breast Cancer Cells, Probiotics and Antimicrobial Proteins (2021)
17. The Non-Apoptotic Role of Caspase-9 Promotes Differentiation in Leukemic Cells, Biochimica et Biophysica Acta - Molecular Cell Research (2019)