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To Be or Not to Be: Navigating the Influence of Micrornas on Cervical Cancer Cell Death Publisher



Taghizadieh M1 ; Kalantari M2 ; Bakhshali R3 ; Kobravi S4 ; Khalilollah S5 ; Baghi HB6 ; Bayat M6 ; Nahand JS6 ; Akhavansigari R7, 8
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Biology, Tehran University of health Sciences, Tehran, Iran
  3. 3. Omid Cancer Center, Ahvaz, Iran
  4. 4. Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Neurosurgery, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  6. 6. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Neurosurgery, University Medical Center Tuebingen, Tuebingen, Germany
  8. 8. Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University, Warsaw, Poland

Source: Cancer Cell International Published:2025


Abstract

With all diagnostic and therapeutic advances, such as surgery, radiation- and chemo-therapy, cervical cancer (CC) is still ranked fourth among the most frequent cancers in women globally. New biomarkers and therapeutic targets are warranted to be discovered for the early detection, treatment, and prognosis of CC. As component of the non-coding RNA’s family, microRNAs (miRNAs) participate in several cellular functions such as cell proliferation, gene expression, many signaling cascades, apoptosis, angiogenesis, etc. MiRNAs can suppress or induce programmed cell death (PCD) pathways by altering their regulatory genes. Besides, abnormal expression of miRNAs weakens or promotes various signaling pathways associated with PCD, resulting in the development of human diseases such as CC. For that reason, understanding the effects that miRNAs exert on the various modes of tumor PCD, and evaluating the potential of miRNAs to serve as targets for induction of cell death and reappearance of chemotherapy. The current study aims to define the effect that miRNAs exert on cell apoptosis, autophagy, pyroptosis, ferroptosis, and anoikis in cervical cancer to investigate possible targets for cervical cancer therapy. Manipulating the PCD pathways by miRNAs could be considered a primary therapeutic strategy for cervical cancer. © The Author(s) 2025.
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