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Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight Publisher



Ghollasi M1 ; Ghasembaglou S2 ; Rahban D3 ; Korani M4 ; Motallebnezhad M5 ; Asadi M6, 7 ; Zarredar H2 ; Salimi A8
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Authors Affiliations
  1. 1. Department of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran
  2. 2. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Science, Tabriz, Iran
  3. 3. Department of Nanomedicine, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Basic Oncology, Ege University, Institute of Health Sciences, Izmir, Turkey
  8. 8. Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: International Journal of Stem Cells Published:2021


Abstract

The interactions between the tumor microenvironment and the tumor cells confers a condition that accelerate or decelerate the development of tumor. Of these cells, mesenchymal stem cells (MSCs) have the potential to modulate the tumor cells. MSCs have been established with double functions, whereby contribute to a tumorigenic or anti-tumor setting. Clinical studies have indicated the potential of MSCs to be used as tool in treating the human cancer cells. One of the advantageous features of MSCs that make them as a well-suited tool for cancer therapy is the natural tumor-trophic migration potential. A key specification of the tumor development has been stablished to be angiogenesis. As a result, manipulation of angiogenesis has become an attractive approach for cancer therapy. This review article will seek to clarify the anti-angiogenesis strategy in modulating the MSCs to treat the tumor cells. © 2021. by the Korean Society for Stem Cell Research
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