Dietary Consumption of Advanced Glycation End Products and Risk of Metabolic Syndrome Publisher Pubmed



Angoorani P¹ ; Ejtahed HS^{2, 3} ; Mirmiran P^{1, 4} ; Mirzaei S¹ ; Azizi F⁵
Source: International Journal of Food Sciences and Nutrition Published:2016

Abstract

Metabolic syndrome (MetS) is a complex disorder which has become one of the major public health challenges worldwide. This study was conducted to evaluate the association between dietary advanced glycation end products (AGEs) and risk of MetS and its components. This cross-sectional study was conducted in a representative sample of 5848 adults, aged 19-70 years. Daily consumption of carboxymethyl lysine, a major type of AGEs, was determined using a validated semi-quantitative food frequency questionnaire. Across increasing trend of AGEs consumption, the percentage of fat intake increased and that of carbohydrate significantly decreased (p<0.001). Subjects in the highest (>10 506 kU/d) compared to the lowest (<6673 kU/d) quartile category of AGEs had higher risk of abdominal obesity (OR: 1.19, 95% CI: 1.01-1.39) and hypertriglyceridemia (OR: 1.26, 95% CI: 1.07-1.49). Therefore, recommendation on restriction of AGEs intake could be a practical approach to prevent metabolic abnormalities. © 2016 Taylor & Francis.