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Lung Transplantation As a Way to Escape Pneumonia in Patients With Covid-19: Lessons From Ards and Influenza Pubmed



Khozani RS1 ; Shekouh D2 ; Hosseini SA3 ; Torbati MS4 ; Noorian M5 ; Rabiei R6 ; Mohseni Q3 ; Rad HR3 ; Bojd SS7 ; Hosseini P8 ; Ansari A9 ; Godazandeh K10 ; Deravi N7
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, Venom and Biotherapeutics Molecules Lab, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Student Research Committee, School of Medicine, Zahedan Azad University of Medical Sciences, Zahedan, Iran
  5. 5. Student Research Committee, School of Medicine, Hamadan University of Medical Science, Hamadan, Iran
  6. 6. Student Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran
  7. 7. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  10. 10. UCL Medical School, United Kingdom

Source: Acta Medica Indonesiana Published:2021


Abstract

In this era, the novel Coronavirus, referred to as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a life-threatening virus with a high mortality rate (4.2%) and with no absolute treatment as of yet, may ultimately result in acute respiratory distress syndrome (ARDS). ARDS is one of the fatal complications, highlighted by pulmonary infiltration and severe hypoxemia. This condition can be developed from primary lung inflammation caused by various viruses, particularly influenza viruses, some of the most common human pathogens. Due to this issue, many studies explored several approaches for ARDS treatment. Lung transplantation has been claimed as an efficient cure for severe ARDS and Influenza, which can also be offered for treating critical lung complications of SARS-CoV-2. Thereupon, to the best of our knowledge for the first time, we aimed to review all available data about capability of lung transplantation for the treatment of critically ill patients with ARDS, Influenza, and SARS-CoV-2. © 2021, Indonesian Society of Internal Medicine. All rights reserved.
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