Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples

Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples Publisher

Jahangiri M¹ ; Khosravi S¹ ; Moghtaderi H¹ ; Ranjbar M¹ ; Abadijoo H¹ ; Sarmadi S² ; Izadimood N² ; Shirali E³ ; Hoseinpour P⁴ ; Gity M^{5, 6} ; Abbasvandi F⁷ ; Mohajerzadeh L⁸ ; Aghdam MK⁹ ; Abdolahad M¹

Show Affiliations

1. Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab., School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, Tehran, 14395/515, Iran
2. Department of Pathology, Yas Hospital, Tehran University of Medical Sciences, P.O. Box 14155/6447, Tehran, Iran
3. Gynecology Department, Yas Hospital, Tehran University of Medical Sciences, P.O. Box 14155/6447, Tehran, Iran
4. Central Lab of Breast Pathobiology, SEPAS Lab, Tehran, Iran
5. Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, P.O. Box 14155/6447, Tehran, Iran
6. Department of Radiology, Medical Imaging Center, Tehran University of Medical Sciences, P.O. Box 14155/6447, Tehran, Iran
7. Clinic of Surgery, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. Box 15179/64311, Tehran, Iran
8. Pediatric Surgery Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, P.O. Box. 19395-4719, Tehran, Iran
9. Pediatric Pathology Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, P.O. Box. 19395-4719, Tehran, Iran

Source: Sensors and Actuators# B: Chemical Published:2019

Abstract

A microfluidic electrical actuator in the form of a cytological slide has been developed to separate and relocate atypical/cancer cells of liquid cytology samples (such as fine needle aspiration, uterine cervical smear and bone marrow aspiration) in a limited space for fast and precise pathological evaluation. The mechanism of this system named smart cytological slide (SCS) was based on the tendency of atypical/neoplastic cells, which have significant negative membrane charges, to positive pole region of direct electric field applied by the patterned gold microelectrodes of the actuator. Results of SCS on cytological samples of 70 patients showed better separating profile with much greater efficacy and selectivity than conventional cytological slides (CCS). Moreover, SCS detected the false negative responses of CCS in 5% of the samples while we used from the residues of the samples in SCS tests. © 2019 Elsevier B.V.

2. Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood, Biosensors and Bioelectronics (2021)

3. Carbon Nanotube Based Dielectric Spectroscopy of Tumor Secretion; Electrochemical Lipidomics for Cancer Diagnosis, Biosensors and Bioelectronics (2019)

4. Positive Electrostatic Therapy of Metastatic Tumors: Selective Induction of Apoptosis in Cancer Cells by Pure Charges, Cancer Medicine (2021)

5. Prognostic and Therapeutic Significance of Circulating Tumor Cells in Patients With Lung Cancer, Cellular Oncology (2020)

6. Effective Boundary Correction for Deterministic Lateral Displacement Microchannels to Improve Cell Separation: A Numerical and Experimental Study, Biosensors (2024)

7. Bioelectronics of the Cellular Cytoskeleton: Monitoring Cytoskeletal Conductance Variation for Sensing Drug Resistance, ACS Sensors (2019)

8. A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients, Frontiers in Medicine (2023)

Experts (# of related papers)

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Masoumeh Gity (1)

Seyed Hamidollah Ghaffari (1)

Style	Citing Format
MLA	Jahangiri M, et al.. "Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples." Sensors and Actuators# B: Chemical, vol. 297, no. , 2019, pp. -.
APA	Jahangiri M, Khosravi S, Moghtaderi H, Ranjbar M, Abadijoo H, Sarmadi S, Izadimood N, Shirali E, Hoseinpour P, Gity M, Abbasvandi F, Mohajerzadeh L, Aghdam MK, Abdolahad M (2019). Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples. Sensors and Actuators# B: Chemical, 297(), -.
Chicago	Jahangiri M, Khosravi S, Moghtaderi H, Ranjbar M, Abadijoo H, Sarmadi S, Izadimood N, et al.. "Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples." Sensors and Actuators# B: Chemical 297, no. (2019): -.
Harvard	Jahangiri M et al. (2019) 'Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples', Sensors and Actuators# B: Chemical, 297(), pp. -.
Vancouver	Jahangiri M, Khosravi S, Moghtaderi H, Ranjbar M, Abadijoo H, Sarmadi S, et al.. Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples. Sensors and Actuators# B: Chemical. 2019;297():-.
BibTex	@article{ author = {Jahangiri M and Khosravi S and Moghtaderi H and Ranjbar M and Abadijoo H and Sarmadi S and Izadimood N and Shirali E and Hoseinpour P and Gity M and Abbasvandi F and Mohajerzadeh L and Aghdam MK and Abdolahad M}, title = {Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples}, journal = {Sensors and Actuators# B: Chemical}, volume = {297}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Jahangiri M AU - Khosravi S AU - Moghtaderi H AU - Ranjbar M AU - Abadijoo H AU - Sarmadi S AU - Izadimood N AU - Shirali E AU - Hoseinpour P AU - Gity M AU - Abbasvandi F AU - Mohajerzadeh L AU - Aghdam MK AU - Abdolahad M TI - Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples JO - Sensors and Actuators# B: Chemical VL - 297 IS - SP - EP - PY - 2019 ER -

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