Green Synthesis of Silver Nanoparticles Using Zingiber Officinale and Thymus Vulgaris Extracts: Characterisation, Cell Cytotoxicity, and Its Antifungal Activity Against Candida Albicans in Comparison to Fluconazole

Green Synthesis of Silver Nanoparticles Using Zingiber Officinale and Thymus Vulgaris Extracts: Characterisation, Cell Cytotoxicity, and Its Antifungal Activity Against Candida Albicans in Comparison to Fluconazole Publisher Pubmed

Mohammadi M¹ ; Shahisaraee SA² ; Tavajjohi A³ ; Pournoori N⁴ ; Muhammadnejad S⁵ ; Mohammadi SR² ; Poursalehi R¹ ; Hamid Delavari H¹

Show Affiliations

1. Department of Materials Engineering, Tarbiat Modares University, P.O. Box 14115-143, Tehran, Iran
2. Department of Medical Mycology, Tarbiat Modares University, Tehran, Iran
3. Department of Biology, Islamic Azad University of Shahr Rey, Tehran, Iran
4. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
5. Cell-Based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: IET Nanobiotechnology Published:2019

Abstract

Fluconazole (FLZ) application as a highly successful commercial antifungal azole agent to treat the fungal infections is limited due to emergence of FLZ-resistant candida. In this study, the potential of green synthesised silver nanoparticles (NPs) as an antifungal agent against Candida albicans fungal pathogen is investigated. The extract of ginger (Zingiber officinale) and thyme (Thymus vulgaris) plays as reducing agent, capping agent and antifungal agent. The UV-visible spectroscopy shows the peak of surface plasmon resonance of synthesised Ag NPs after a period of time. The synthesised Ag NPs are spherical, with average sizes of 12 and 18 nm based on ginger and thyme extract, respectively. Fourier transform infrared spectroscopy confirms the adsorption of the plant extract on the surface of the as-prepared Ag NPs. Based on the minimum inhibitory concentration (MIC) method against Candida albicans, the antifungal activity of as-prepared green synthesised Ag NPs shows higher inhibitory in comparison to FLZ. Finally, the Ag NPs synthesised via thyme extract shows no cytotoxicity with concentration below 3.5 ppm, which can be considered as an appropriate candidate instead of FLZ to treat the superficial fungal infections. © 2019 Institution of Engineering and Technology. All rights reserved.

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Style	Citing Format
MLA	Mohammadi M, et al.. "Green Synthesis of Silver Nanoparticles Using Zingiber Officinale and Thymus Vulgaris Extracts: Characterisation, Cell Cytotoxicity, and Its Antifungal Activity Against Candida Albicans in Comparison to Fluconazole." IET Nanobiotechnology, vol. 13, no. 2, 2019, pp. 114-119.
APA	Mohammadi M, Shahisaraee SA, Tavajjohi A, Pournoori N, Muhammadnejad S, Mohammadi SR, Poursalehi R, Hamid Delavari H (2019). Green Synthesis of Silver Nanoparticles Using Zingiber Officinale and Thymus Vulgaris Extracts: Characterisation, Cell Cytotoxicity, and Its Antifungal Activity Against Candida Albicans in Comparison to Fluconazole. IET Nanobiotechnology, 13(2), 114-119.
Chicago	Mohammadi M, Shahisaraee SA, Tavajjohi A, Pournoori N, Muhammadnejad S, Mohammadi SR, Poursalehi R, Hamid Delavari H. "Green Synthesis of Silver Nanoparticles Using Zingiber Officinale and Thymus Vulgaris Extracts: Characterisation, Cell Cytotoxicity, and Its Antifungal Activity Against Candida Albicans in Comparison to Fluconazole." IET Nanobiotechnology 13, no. 2 (2019): 114-119.
Harvard	Mohammadi M et al. (2019) 'Green Synthesis of Silver Nanoparticles Using Zingiber Officinale and Thymus Vulgaris Extracts: Characterisation, Cell Cytotoxicity, and Its Antifungal Activity Against Candida Albicans in Comparison to Fluconazole', IET Nanobiotechnology, 13(2), pp. 114-119.
Vancouver	Mohammadi M, Shahisaraee SA, Tavajjohi A, Pournoori N, Muhammadnejad S, Mohammadi SR, et al.. Green Synthesis of Silver Nanoparticles Using Zingiber Officinale and Thymus Vulgaris Extracts: Characterisation, Cell Cytotoxicity, and Its Antifungal Activity Against Candida Albicans in Comparison to Fluconazole. IET Nanobiotechnology. 2019;13(2):114-119.
BibTex	@article{ author = {Mohammadi M and Shahisaraee SA and Tavajjohi A and Pournoori N and Muhammadnejad S and Mohammadi SR and Poursalehi R and Hamid Delavari H}, title = {Green Synthesis of Silver Nanoparticles Using Zingiber Officinale and Thymus Vulgaris Extracts: Characterisation, Cell Cytotoxicity, and Its Antifungal Activity Against Candida Albicans in Comparison to Fluconazole}, journal = {IET Nanobiotechnology}, volume = {13}, number = {2}, pages = {114-119}, year = {2019} }
RIS	TY - JOUR AU - Mohammadi M AU - Shahisaraee SA AU - Tavajjohi A AU - Pournoori N AU - Muhammadnejad S AU - Mohammadi SR AU - Poursalehi R AU - Hamid Delavari H TI - Green Synthesis of Silver Nanoparticles Using Zingiber Officinale and Thymus Vulgaris Extracts: Characterisation, Cell Cytotoxicity, and Its Antifungal Activity Against Candida Albicans in Comparison to Fluconazole JO - IET Nanobiotechnology VL - 13 IS - 2 SP - 114 EP - 119 PY - 2019 ER -

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