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Green Methods for the Preparation of Mgo Nanomaterials and Their Drug Delivery, Anti-Cancer and Anti-Bacterial Potentials: A Review Publisher



Nejati M1 ; Rostami M2, 3 ; Mirzaei H1 ; Rahiminasrabadi M4, 5, 11 ; Vosoughifar M6 ; Nasab AS7, 8 ; Ganjali MR9, 10
Authors
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Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  3. 3. International Iberian Nanotechnology Laboratory (INL), Braga, 4715-330, Portugal
  4. 4. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
  6. 6. Institute of Nano Science and Nano Technology, University of Kashan, Kashan, Iran
  7. 7. Autoimmune diseases research center, Kashan University of Medical Sciences, Kashan, Iran
  8. 8. Core Research Lab, Kashan University of Medical Sciences, Kashan, Iran
  9. 9. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  10. 10. Biosensor Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Institute of Electronic and Sensor Materials, TU Bergakademie Freiberg, Freiberg, 09599, Germany

Source: Inorganic Chemistry Communications Published:2022


Abstract

This paper focuses on magnesium oxide and hydroxide, which are compounds with favorable and exclusive features for various applications. Magnesium oxide nanoparticles (MgO NPs) have been reportedly produced through green synthesis procedures. Natural materials or their products including plants extracts or those of plants parts, roots, fruits, and gums have been used as reducing and capping agents in the synthesis procedures. MgO nanostructures have been reportedly used in drug delivery, anti-cancer and anti-bacterial applications, which has increased the risks of human exposure to these materials. A full understanding of the influence of MgO NPs and the underlying mechanisms of their actions are important in evaluating the environmental risks of using these nanoparticles. MgO NPs are known to enjoy high biocompatibility and stability, and low IC50 values in comparison with copper, manganese, tin, cobalt, manganese oxide nanoparticles. This has been attributed to the great bioavailability, and lower toxicity (hemolytic investigations) of these particles. MgO NPs are also known as effective chemotherapeutic and bacteriostatic agents for use in the fast detection and diagnosis of various cancers. However, more studies should be aimed at evaluating the toxic effects of MgO NPs on individual organism. As a first step, this review attempts to shed some light on the advancements in the area of green synthesis for preparing efficient NPs including MgO for future applications. © 2021 Elsevier B.V.
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