Can Cerebellar Neurodevelopmental Disorders Affect Behavioral Disorders or Vice Versa? Publisher



Mohammad Jafari R¹ ; Shadboorestan A² ; Saeedi Saravi SS^{1, 3, 4} ; Dehpour AR^{1, 3} Show Affiliations
Source: Contemporary Clinical Neuroscience Published:2023

Abstract

Recent investigations have been focused on understanding the role of the cerebellum in non-motor behaviors and of the cerebellar dysfunction in neurodevelopmental, neurobehavioral, and schizo-affective disorders. Non-motor behaviors, including emotion, cognition, and social behavior, seem to be modified by impairment of the cerebellar structure-function relationship. Clinically, these behavioral defects have been observed in patients with autism spectrum disorders (ASD), attention deficit-hyperactivity disorder (ADHD), and schizophrenia. These behavioral outcomes have been demonstrated to be associated with prenatal and/or early postnatal damages of cerebro-cerebellar circuits. Understanding the cerebellum’s essential role in early neurodevelopment, and the association between cerebellar injury and long-term alteration in behavior is crucial. This chapter attempts to summarize the recent evidence of involvement of the cerebellum in neurodevelopment and behavior, and that both these views remain to be revised for declaration of the paradoxical relationship between cerebellar function and behavioral despair, as well as, neurodevelopmental disorders including ASD and ADHD. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.