Cardiac Considerations in Hematopoietic Stem Cell Transplantation (Hsct) for Transfusion-Dependent Thalassemia: A Review Publisher

Summary: Heart issues may complicate HSCT for transfusion-dependent thalassemia patients. Are these risks worth it for a potential cure? Research suggests careful consideration is crucial. #HSCT #Thalassemia

Nateghi S¹ ; Rasooli A² ; Moaddabshoar L³ ; Panahi Z⁴ ; Rostami MR^{5, 6}
Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2025

Abstract

Hematopoietic stem cell transplantation (HSCT) is considered a potentially curative treatment for several malignant and non-malignant hematologic disorders including transfusion-dependent thalassemia (TDT). However, HSCT is associated with short-term and long-term complications. One of the recognized causes of morbidity and mortality in TDT patients is heart-related complications. Additionally, cardiac involvement is likely to be more common in patients who proceed to HSCT. So the risks of cardiac complications should be carefully weighed against the advantages of the primary disease cure. This review aims to discuss the cardiac considerations that should be kept in mind in TDT patients going through the path of HSCT. © 2025 Tehran University of Medical Sciences.