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Psychosocial Stress, Blood Brain Barrier and the Development of Anti N-Methyl-D-Aspartate Receptor (Nmdar) Encephalitis Publisher Pubmed



Vahabi Z1, 2 ; Etesam F3 ; Zandifar A4, 5 ; Badrfam R6, 7
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Authors Affiliations
  1. 1. Geriatric Department, Ziaeean Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Memory and Behavioral Neurology Division, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Psychosomatic Medicine Research Center, Department of Psychiatry, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cardiovascular Research Center, Shahid Rajaei Educational & Medical Center, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Psychosomatic Medicine Research Center, Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Psychiatry, Roozbeh Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Multiple Sclerosis and Related Disorders Published:2021


Abstract

Throughout life, mechanisms such as damage and inflammation can alter the permeability of the blood-brain barrier(BBB). According to some studies, increasing the permeability of the blood-brain barrier can occur in a time-dependent manner following restraint stress. On the other hand, there have been reports of increased N-Methyl-D-Aspartate Receptor (NMDAR) -Ab seroprevalence in chronic stress conditions. The presence of antibody-secreting cells / memory B cells in the intrathecal area of the brain and their redistribution under various environmental stresses, which can be independent of the BBB status, are other points in this area that can emphasize the role of environmental stress in Anti NMDAR encephalitis. © 2021
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