Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Three Markers in Cancerous and Healthy Cells of Patients With Non-Small-Cell Lung Carcinoma (Nsclc) Publisher Pubmed



Jamaati H1 ; Khosravi A2 ; Abedini A3 ; Kiani A3 ; Tabarsi P4 ; Dargahi H5 ; Bahrami N6, 7 ; Dizaji MK8 ; Beigee FS9 ; Pourabdollah M1 ; Gheysouri A1 ; Ahmadian N10 ; Abniki M11 ; Mohamadnia A1, 12 Show All Authors
Authors
  1. Jamaati H1
  2. Khosravi A2
  3. Abedini A3
  4. Kiani A3
  5. Tabarsi P4
  6. Dargahi H5
  7. Bahrami N6, 7
  8. Dizaji MK8
  9. Beigee FS9
  10. Pourabdollah M1
  11. Gheysouri A1
  12. Ahmadian N10
  13. Abniki M11
  14. Mohamadnia A1, 12
  15. Velayati A13
Show Affiliations
Authors Affiliations
  1. 1. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Allied Medicine, Health Information Management Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Biostatistics Department, Mycobacteriology research center, National research institute of Tuberculosis and lung Disease (NriTlD), Masih Daneshvari Hospital, Shahid Beheshti university of Medical Sciences, Iran
  9. 9. Lung transplantation research center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Transplantation Center, Department of Curative Affairs, Ministry of Health and Medical Education, Tehran, Iran
  11. 11. Department of Biotechnology, Faculty of Sciences, Islamic Azad University, Tehran, Iran
  12. 12. School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  13. 13. Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Asian Pacific Journal of Cancer Prevention Published:2019


Abstract

Introduction: Lung cancer is the most common cause of cancer-related death among males and females. The diagnosis of lung cancer is of great importance for clinical considerations and follow-up treatment. This study aimed to examine the expression of CEA, LUNX, and CK19 biomarkers in the cancerous and healthy tissues of patients suffering from NSCLC. Methods: In this study, 30 patients with NSCLCs referring to Masih Daneshvari Hospital in Tehran were voluntarily selected prior to taking any treatment. A tissue sample from the center and a sample of healthy tissues close to the cancerous masses were prepared by a specialist in the bronchoscopy sector and tested using real-time RT-PCR. Results: Positive CEA mRNA was observed in cancerous tissues in the center of tumors of 25 out of 30 cases. In the healthy tissue group, the same was found in 10 out of 30 cases (P < 0.001). The markers CK19 and LUNX mRNAs showed to be positive in cancerous samples in the center of tumors of 15 and 22 out of 30 cases, and in the healthy tissue group, the expression was observed in 5 and 4 out of 30 cases, respectively(P < 0.001). Conclusion: This study confirms that the aformentioed markers are the ones with a relatively appropriate sensitivity and specificity for the diagnosis of lung cancer. © 2019 Asian Pacific Organization for Cancer Prevention.
Related Docs
1. Expression of Two Basic Mrna Biomarkers in Peripheral Blood of Patients With Non-Small Cell Lung Cancer Detected by Real-Time Rt-Pcr, Individually and Simultaneously, Iranian Biomedical Journal (2015)
2. Expression of Two Essential Mrna Biomarker in the Peripheral Blood As Possible Biomarkers for Diagnosis of Non-Small Cell Lung Carcinoma, Minerva Pneumologica (2016)
3. Diagnostic Value of Lunx Mrna and Cea Mrna Expression in Pleural Fluid of Patients With Non-Small Cell Lung Cancer, Minerva Pneumologica (2017)
4. Expression of Ck19-Mrna and Cea-Mrna Biomarkers in Pleural Fluid of Patients With Non-Small Cell Lung Cancer, Minerva Pneumologica (2017)
5. Detection of Vascular Endothelial Growth Factor Messenger Rna (Vegf Mrna), Cytokeratin-19 Mrna (Ck19 Mrna), and Vascular Endothelial Growth Factor (Vegf) Protein Biomarker in the Peripheral Blood of Patients With Breast Cancer, Journal of Isfahan Medical School (2017)
6. Multi-Gene Expression in Anthracosis of the Lungs As One of the Risk Factors for Non-Small Cell Lung Cancer, Asian Pacific Journal of Cancer Prevention (2017)
Experts (# of related papers)
Naghmeh Bahrami (6)
Hossein Dargahi (1)