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The Analgesic Effect of Salvia Reuterana Publisher



Esfahani HM1 ; Amirshahrokhi K2 ; Mashmool A1 ; Farimani MM3 ; Dehpour A4 ; Miran M5
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
  3. 3. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
  4. 4. Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pharmacognosy and Biotechnology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran

Source: Iranian Journal of Pharmaceutical Sciences Published:2021


Abstract

Salvia reuterana, commonly known as Maryam Goli Esfahani, is a member of the Labiateae family. In Iranian folk medicine, aerial parts of S. reuterana have been used as sedative and anxiety. Evaluation of various extracts of the plant for their analgesic activity revealed that treatment of mice with n-hexane extract (500 mg/kg, i.p.) significantly increased the latency time as compared to the control group. Fractionation of the hexane extract of S. reuterana led to the isolation of sclareol as the main compound (0.19% w/w). Column chromatography was used to isolation of compounds from S. reuterana and a spectroscopic method including NMR was used to identification of the isolated compound. Evaluation of the analgesic effect of sclareol using a hot plate, tail-flick, and formalin tests in mice confirmed the potent analgesic effect of sclareol as an effective compound of S. reuterana. These results showed that the n-hexane extract of aerial parts of S. reuterana and its main constituent sclareol showed significant analgesic activity in different rodent nociceptive behavioral tests. © 2021, Iranian Association of Pharmaceutical Scientists. All rights reserved.
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