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Covid-19 Cases, Hospitalizations and Deaths After Vaccination: A Cohort Event Monitoring Study, Islamic Republic of Iran; [Cas, Hospitalisations Et Deces Lies a La Covid-19 Apres La Vaccination: Etude De Cohorte Portant Sur La Surveillance Des Evenements En Republique Islamique D'iran]; [Casos, Hospitalizaciones Y Muertes Por La Covid-19 Tras La Vacunacion: Un Estudio De Cohortes Sobre El Seguimiento De Eventos En La Republica Islamica De Iran] Publisher Pubmed



Hosseinzadeh A1 ; Sahabnegah S2 ; Nili S3 ; Aliyari R4 ; Goli S1 ; Fereidouni M5 ; Alami A6 ; Shati M7 ; Ahmadnezhad E8 ; Mehravaran S9 ; Fateh M10 ; Khajeha H4 ; Emamian Z11 ; Behmanesh E11 Show All Authors
Authors
  1. Hosseinzadeh A1
  2. Sahabnegah S2
  3. Nili S3
  4. Aliyari R4
  5. Goli S1
  6. Fereidouni M5
  7. Alami A6
  8. Shati M7
  9. Ahmadnezhad E8
  10. Mehravaran S9
  11. Fateh M10
  12. Khajeha H4
  13. Emamian Z11
  14. Behmanesh E11
  15. Mahdavi S1
  16. Enayatrad M12
  17. Shahrbabaki PM13
  18. Ansarimoghaddam A14
  19. Heidarzadeh A15
  20. Shahrakisanavi F14
  21. Shahri SMH16
  22. Dehghan M13
  23. Moridani MA17
  24. Sheibani H18
  25. Abbaszadeh M18
  26. Jafari R19
  27. Valikhani M18
  28. Binesh E18
  29. Vahedi H18
  30. Chaman R1
  31. Khodashahi R20
  32. Amini M21
  33. Azad FJ22
  34. Rezaeitalab F2
  35. Jamehdar SA23
  36. Eshraghi A24
  37. Sharifi H25
  38. Bajgani SMH26
  39. Mahdavi A27
  40. Jafarzadeh A28
  41. Farokhnia M29
  42. Ebrahimi S30
  43. Pardakhti A31
  44. Ghaderi E32
  45. Soltani H33
  46. Jadidoleslami S34
  47. Arianejad A34
  48. Gavili H34
  49. Moradveisi B35
  50. Motamedi D36
  51. Zare H5
  52. Kazemi T37
  53. Emamian MH4
Show Affiliations
Authors Affiliations
  1. 1. School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran
  2. 2. Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Faculty of Health, Kurdistan University of Medical Sciences, Sanandaj, Iran
  4. 4. Ophthalmic Epidemiology Research Center, Shahroud University of Medical Sciences, 7 Tir Square, Shahroud, 3614773947, Iran
  5. 5. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
  6. 6. Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
  7. 7. Department of Epidemiology, Iran University of Medical Sciences, Tehran, Iran
  8. 8. National Institute for Health Research, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. School of Computer Mathematics and Natural Sciences, Morgan State University, Baltimore, United States
  10. 10. Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran
  11. 11. Health Technology Incubator Center, Shahroud University of Medical Sciences, Shahroud, Iran
  12. 12. Bahar Clinical Research Development Unit, Shahroud University of Medical Sciences, Shahroud, Iran
  13. 13. Razi Faculty of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran
  14. 14. Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  15. 15. School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  16. 16. Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  17. 17. Vice-Chancellery for Health Affairs, Guilan University of Medical Sciences, Rasht, Iran
  18. 18. Imam Hossein Clinical Research Development Unit, Shahroud University of Medical Sciences, Shahroud, Iran
  19. 19. School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran
  20. 20. Department of Infectious Diseases and Tropical Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  21. 21. Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  22. 22. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  23. 23. Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  24. 24. Department of Cardiology, Mashhad University of Medical Sciences, Mashhad, Iran
  25. 25. HIV/STI Surveillance Research Center, Kerman University of Medical Sciences, Kerman, Iran
  26. 26. Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Iran
  27. 27. Cardiovascular Research Centre, Kerman University of Medical Sciences, Kerman, Iran
  28. 28. Department of Immunology, Kerman University of Medical Sciences, Kerman, Iran
  29. 29. Research Center for Hydatid Disease, Kerman University of Medical Sciences, Kerman, Iran
  30. 30. Department of Medical Microbiology (Bacteriology & Virology), Kerman University of Medical Sciences, Kerman, Iran
  31. 31. Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
  32. 32. Zoonoses Research Center, Kurdistan University of Medical Science, Sanandaj, Iran
  33. 33. Vice-Chancellery for Health Affairs, Kurdistan University of Medical Sciences, Sanandaj, Iran
  34. 34. Vice-Chancellery for Clinical Affairs, Kurdistan University of Medical Sciences, Sanandaj, Iran
  35. 35. Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran
  36. 36. Department of Neurology, Kurdistan University of Medical Sciences, Sanandaj, Iran
  37. 37. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

Source: Bulletin of the World Health Organization Published:2022


Abstract

Objective To investigate the incidence of coronavirus disease 2019 (COVID-19) cases, hospitalizations and deaths in Iranians vaccinated with either AZD1222 Vaxzevria, CovIran® vaccine, SARS-CoV-2 Vaccine (Vero Cell), Inactivated (lnCoV) or Sputnik V. Methods We enrolled individuals 18 years or older receiving their first COVID-19 vaccine dose between April 2021 and January 2022 in seven Iranian cities. Participants completed weekly follow-up surveys for 17 weeks (25 weeks for AZD1222) to report their COVID-19 status and hospitalization. We used Cox regression models to assess risk factors for contracting COVID-19, hospitalization and death. Findings Of 89 783 participants enrolled, incidence rates per 1 000 000 person-days were: 528.2 (95% confidence interval, CI: 514.0–542.7) for contracting COVID-19; 55.8 (95% CI: 51.4–60.5) for hospitalization; and 4.1 (95% CI: 3.0–5.5) for death. Compared with SARS-CoV-2 Vaccine (Vero Cell), hazard ratios (HR) for contracting COVID-19 were: 0.70 (95% CI: 0.61−0.80) with AZD1222; 0.73 (95% CI: 0.62–0.86) with Sputnik V; and 0.73 (95% CI: 0.63–0.86) with CovIran®. For hospitalization and death, all vaccines provided similar protection 14 days after the second dose. History of COVID-19 protected against contracting COVID-19 again (HR: 0.76; 95% CI: 0.69–0.84). Diabetes and respiratory, cardiac and renal disease were associated with higher risks of contracting COVID-19 after vaccination. Conclusion The rates of contracting COVID-19 after vaccination were relatively high. SARS-CoV-2 Vaccine (Vero Cell) provided lower protection against COVID-19 than other vaccines. People with comorbidities had higher risks of contracting COVID-19 and hospitalization and should be prioritized for preventive interventions. © 2022, World Health Organization. All rights reserved.