Association of Hippo Signalling Pathway With Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Review

Association of Hippo Signalling Pathway With Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Review Publisher Pubmed

Motavalli R^{1, 2, 3} ; Marofi F⁴ ; Nasimi M⁵ ; Yousefi M⁶ ; Khiavi FM^{7, 8}

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1. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2. Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3. Tabriz University of Medical Science, Tabriz, Iran
4. Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5. Associate professor of Dermatology, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
7. Department of Virology, Pasteur Institute of Iran, Tehran, Iran
8. Medical Biotechnology Research Center, AJA University of Medical Sciences, Tehran, Iran

Source: Anti-Cancer Agents in Medicinal Chemistry Published:2021

Abstract

Hippo signalling pathway that is evolutionarily conserved affects diver’s pathology and physiology processes, including tissue repair, wound healing, tissue size and tissue regeneration. Epigenetic changes are post-translational modifications in DNA proteins and histones. Epigenetic changes including histone acetylation and deacetylation, miRNAs dysregulation, and aberrant DNA methylation, inflammatory genes actives abnormal in Hippo signaling pathway. Using some treatments, including Histone deacetylases (HDACs), herbal composition, siRNAs and long non-Coding RNA (lncRNA) for suppressing cancer cells by targeting Hippo pathways, may open new views in cancer target therapy fields. The aim of this review study is firstly to demonstrate the importance of Hippo signalling and its association with epigenetic changes in cancer and then to demonstrate progress in targeting Hippo signalling in cancer therapy. © 2021 Bentham Science Publishers.

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Style	Citing Format
MLA	Motavalli R, et al.. "Association of Hippo Signalling Pathway With Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Review." Anti-Cancer Agents in Medicinal Chemistry, vol. 21, no. 12, 2021, pp. 1520-1528.
APA	Motavalli R, Marofi F, Nasimi M, Yousefi M, Khiavi FM (2021). Association of Hippo Signalling Pathway With Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Review. Anti-Cancer Agents in Medicinal Chemistry, 21(12), 1520-1528.
Chicago	Motavalli R, Marofi F, Nasimi M, Yousefi M, Khiavi FM. "Association of Hippo Signalling Pathway With Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Review." Anti-Cancer Agents in Medicinal Chemistry 21, no. 12 (2021): 1520-1528.
Harvard	Motavalli R et al. (2021) 'Association of Hippo Signalling Pathway With Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Review', Anti-Cancer Agents in Medicinal Chemistry, 21(12), pp. 1520-1528.
Vancouver	Motavalli R, Marofi F, Nasimi M, Yousefi M, Khiavi FM. Association of Hippo Signalling Pathway With Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Review. Anti-Cancer Agents in Medicinal Chemistry. 2021;21(12):1520-1528.
BibTex	@article{ author = {Motavalli R and Marofi F and Nasimi M and Yousefi M and Khiavi FM}, title = {Association of Hippo Signalling Pathway With Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Review}, journal = {Anti-Cancer Agents in Medicinal Chemistry}, volume = {21}, number = {12}, pages = {1520-1528}, year = {2021} }
RIS	TY - JOUR AU - Motavalli R AU - Marofi F AU - Nasimi M AU - Yousefi M AU - Khiavi FM TI - Association of Hippo Signalling Pathway With Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Review JO - Anti-Cancer Agents in Medicinal Chemistry VL - 21 IS - 12 SP - 1520 EP - 1528 PY - 2021 ER -

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