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Epi-Drugs and Epi-Mirs: Moving Beyond Current Cancer Therapies Publisher Pubmed



Salarinia R1, 2 ; Sahebkar A3 ; Peyvandi M4, 5 ; Mirzaei HR6 ; Jaafari MR7 ; Riahi MM1 ; Ebrahimnejad H8 ; Nahand JS1 ; Hadjati J9 ; Asrami MO10 ; Fadaei S11 ; Salehi R12 ; Mirzaei H1
Authors

Source: Current Cancer Drug Targets Published:2016


Abstract

Epigenetic modifications determine phenotypic characteristics in a reversible, stable and genotype-independent manner. Epigenetic modifications mainly encompass CpG island methylation and histone modifications, both being important in the pathogenesis of malignancies. The reversibility of epigenetic phenomenon provides a suitable therapeutic option that is reactivation of epigenetically silenced tumor-suppressor genes. Inhibition of DNA methyltransferase, histone deacetylase and Aurora B kinase, individually or collectively, could feasibly prevent or reverse the impact of epigenetic silencing. MicroRNAs [miRNAs] are an important layer of epigenetic controlling of gene expression, and serve as diagnostic and prognostic biomarkers as well as treatment targets for several types of cancer. miRNAs are involved inepigenetically silencing or activation of genes, tumor suppressor genes and oncogenes, and their modulation opens new horizons for designing novel cancer therapeutic agents. © 2016 Bentham Science Publishers.
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