In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy

In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy Publisher Pubmed

Mohammadinejad R¹ ; Dehshahri A² ; Sagar Madamsetty V³ ; Zahmatkeshan M^{4, 5} ; Tavakol S⁴ ; Makvandi P^{6, 7} ; Khorsandi D^{8, 9} ; Pardakhty A¹ ; Ashrafizadeh M¹⁰ ; Ghasemipour Afshar E¹¹ ; Zarrabi A^{12, 13}

Show Affiliations

1. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
2. Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran
3. Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, 32224, FL, United States
4. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
5. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
6. Institute for Polymers, Composites and Biomaterials, National Research Council, IPCB-CNR, Naples, Italy
7. Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, 6153753843, Iran
8. Department of Medical Nanotechnology, Faculty of Advanced, Technologies in Medicine, Iran University of Medical Sciences, Tehran, 14496-14535, Iran
9. Department of Biotechnology-Biomedicine, University of Barcelona, Barcelona, 08028, Spain
10. Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
11. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
12. Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul, 34956, Turkey
13. Center of Excellence for Functional Surfaces and Interfaces (EFSUN), Faculty of Engineering and Natural Sciences, Sabanci University, Tuzla, Istanbul, 34956, Turkey

Source: Journal of Controlled Release Published:2020

Abstract

Gene therapy by expression constructs or down-regulation of certain genes has shown great potential for the treatment of various diseases. The wide clinical application of nucleic acid materials dependents on the development of biocompatible gene carriers. There are enormous various compounds widely investigated to be used as non-viral gene carriers including lipids, polymers, carbon materials, and inorganic structures. In this review, we will discuss the recent discoveries on non-viral gene delivery systems. We will also highlight the in vivo gene delivery mediated by non-viral vectors to treat cancer in different tissue and organs including brain, breast, lung, liver, stomach, and prostate. Finally, we will delineate the state-of-the-art and promising perspective of in vivo gene editing using non-viral nano-vectors. © 2020 Elsevier B.V.

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Style	Citing Format
MLA	Mohammadinejad R, et al.. "In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy." Journal of Controlled Release, vol. 325, no. , 2020, pp. 249-275.
APA	Mohammadinejad R, Dehshahri A, Sagar Madamsetty V, Zahmatkeshan M, Tavakol S, Makvandi P, Khorsandi D, Pardakhty A, Ashrafizadeh M, Ghasemipour Afshar E, Zarrabi A (2020). In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy. Journal of Controlled Release, 325(), 249-275.
Chicago	Mohammadinejad R, Dehshahri A, Sagar Madamsetty V, Zahmatkeshan M, Tavakol S, Makvandi P, Khorsandi D, et al.. "In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy." Journal of Controlled Release 325, no. (2020): 249-275.
Harvard	Mohammadinejad R et al. (2020) 'In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy', Journal of Controlled Release, 325(), pp. 249-275.
Vancouver	Mohammadinejad R, Dehshahri A, Sagar Madamsetty V, Zahmatkeshan M, Tavakol S, Makvandi P, et al.. In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy. Journal of Controlled Release. 2020;325():249-275.
BibTex	@article{ author = {Mohammadinejad R and Dehshahri A and Sagar Madamsetty V and Zahmatkeshan M and Tavakol S and Makvandi P and Khorsandi D and Pardakhty A and Ashrafizadeh M and Ghasemipour Afshar E and Zarrabi A}, title = {In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy}, journal = {Journal of Controlled Release}, volume = {325}, number = {}, pages = {249-275}, year = {2020} }
RIS	TY - JOUR AU - Mohammadinejad R AU - Dehshahri A AU - Sagar Madamsetty V AU - Zahmatkeshan M AU - Tavakol S AU - Makvandi P AU - Khorsandi D AU - Pardakhty A AU - Ashrafizadeh M AU - Ghasemipour Afshar E AU - Zarrabi A TI - In Vivo Gene Delivery Mediated by Non-Viral Vectors for Cancer Therapy JO - Journal of Controlled Release VL - 325 IS - SP - 249 EP - 275 PY - 2020 ER -

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