Depth of Invasion and Extranodal Extension: The Influential Factors to Predict Survival Rate of Patients With Oral Tongue Squamous Cell Carcinoma

Depth of Invasion and Extranodal Extension: The Influential Factors to Predict Survival Rate of Patients With Oral Tongue Squamous Cell Carcinoma Publisher Pubmed

Ghorbanpour M¹ ; Salarvand S² ; Salarvand S² ; Shahsavari F¹ ; Shirkhoda M⁴ ; Shakib PA⁵ ; Ghalehtaki R^{6, 7}

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1. Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2. Department of Anatomical and Clinical Pathology, Cancer Institute, IKHC, Tehran University of Medical Sciences, Tehran, Iran
3. School of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
4. Department of Oncosurgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Oral and Maxillofacial Pathology Department, Cancer Institute Hospital, IKHC, Tehran University of Medical Sciences, Tehran, Iran
6. Radiation Oncology Research Center (RORC), Cancer Research Institute, Tehran University of Medical Sciences, Qarib St., Tehran, Iran
7. Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Cancer Published:2024

Abstract

Background: Cancer staging is essential in determining patients’ prognoses and designing the appropriate treatment strategy. American Joint Committee on Cancer has released the latest version of the staging system for tongue SCC. However, it is interesting to know whether this change in staging and the addition of depth of invasion (DOI) and the extra-nodal extension (ENE) have any influence on patients’ prognosis. Methods: In this retrospective cohort study, the pathology records of patients with tongue SCC who underwent surgery at the Pathology Department of Cancer Institute Hospital, 2017–2021, were collected by referring to the hospital information system. Then the rate of change of pT, pN, and overall stage were assessed based on American Joint Committee on Cancer 7th and 8th editions. Results: The records of 204 patients were included in the final analysis. Significant changes in the staging system 2021 resulted in upstaging 64 patients (31.4%) in the overall stage, 91 patients (44.6%) in pT, and 30 patients (14.7%) in pN. The survival of upstaged patients was inferior compared to those without upstaging. However, this was not statistically significant for tumor and overall upstaging in the univariate analysis, while those with upstaged pN had significantly shorter survival. In the multivariate analysis, pT upstage also significantly impacted survival. Conclusion: This study showed the importance of pathology reports based on the latest edition of the American Joint Committee on Cancer, the accuracy in examining factors such as depth of invasion and extra-nodal extension. © The Author(s) 2024.

2. Correlation Between Tumor Thickness in Tongue Squamous Cell Carcinoma and Cervical Lymph Node Metastasis, Oral Science International (2025)

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Style	Citing Format
MLA	Ghorbanpour M, et al.. "Depth of Invasion and Extranodal Extension: The Influential Factors to Predict Survival Rate of Patients With Oral Tongue Squamous Cell Carcinoma." BMC Cancer, vol. 24, no. 1, 2024, pp. -.
APA	Ghorbanpour M, Salarvand S, Salarvand S, Shahsavari F, Shirkhoda M, Shakib PA, Ghalehtaki R (2024). Depth of Invasion and Extranodal Extension: The Influential Factors to Predict Survival Rate of Patients With Oral Tongue Squamous Cell Carcinoma. BMC Cancer, 24(1), -.
Chicago	Ghorbanpour M, Salarvand S, Salarvand S, Shahsavari F, Shirkhoda M, Shakib PA, Ghalehtaki R. "Depth of Invasion and Extranodal Extension: The Influential Factors to Predict Survival Rate of Patients With Oral Tongue Squamous Cell Carcinoma." BMC Cancer 24, no. 1 (2024): -.
Harvard	Ghorbanpour M et al. (2024) 'Depth of Invasion and Extranodal Extension: The Influential Factors to Predict Survival Rate of Patients With Oral Tongue Squamous Cell Carcinoma', BMC Cancer, 24(1), pp. -.
Vancouver	Ghorbanpour M, Salarvand S, Salarvand S, Shahsavari F, Shirkhoda M, Shakib PA, et al.. Depth of Invasion and Extranodal Extension: The Influential Factors to Predict Survival Rate of Patients With Oral Tongue Squamous Cell Carcinoma. BMC Cancer. 2024;24(1):-.
BibTex	@article{ author = {Ghorbanpour M and Salarvand S and Salarvand S and Shahsavari F and Shirkhoda M and Shakib PA and Ghalehtaki R}, title = {Depth of Invasion and Extranodal Extension: The Influential Factors to Predict Survival Rate of Patients With Oral Tongue Squamous Cell Carcinoma}, journal = {BMC Cancer}, volume = {24}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Ghorbanpour M AU - Salarvand S AU - Salarvand S AU - Shahsavari F AU - Shirkhoda M AU - Shakib PA AU - Ghalehtaki R TI - Depth of Invasion and Extranodal Extension: The Influential Factors to Predict Survival Rate of Patients With Oral Tongue Squamous Cell Carcinoma JO - BMC Cancer VL - 24 IS - 1 SP - EP - PY - 2024 ER -

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