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Comparative Analysis of Essential Oil Composition of Iranian and Indian Nigella Sativa L. Extracted Using Supercritical Fluid Extraction and Solvent Extraction Publisher Pubmed



Ghahramanloo KH1 ; Kamalidehghan B2 ; Akbari Javar H3 ; Teguh Widodo R1 ; Majidzadeh K4 ; Noordin MI1
Authors
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Authors Affiliations
  1. 1. Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  2. 2. Medical Genetics Department, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
  3. 3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Breast Cancer Research Center (BCRC) Academic Center for Education, Culture and Research, Tehran, Iran

Source: Drug Design# Development and Therapy Published:2017


Abstract

The objective of this study was to compare the oil extraction yield and essential oil composition of Indian and Iranian Nigella sativa L. extracted by using Supercritical Fluid Extraction (SFE) and solvent extraction methods. In this study, a gas chromatography equipped with a mass spectrophotometer detector was employed for qualitative analysis of the essential oil composition of Indian and Iranian N. sativa L. The results indicated that the main fatty acid composition identified in the essential oils extracted by using SFE and solvent extraction were linoleic acid (22.4%–61.85%) and oleic acid (1.64%–18.97%). Thymoquinone (0.72%–21.03%) was found to be the major volatile compound in the extracted N. sativa oil. It was observed that the oil extraction efficiency obtained from SFE was significantly (P<0.05) higher than that achieved by the solvent extraction technique. The present study showed that SFE can be used as a more efficient technique for extraction of N. Sativa L. essential oil, which is composed of higher linoleic acid and thymoquinone contents compared to the essential oil obtained by the solvent extraction technique. © 2017 Ghahramanloo et al.
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