The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study

The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study Publisher Pubmed

Labbaf A¹ ; Ghaedi I¹ ; Alipoor B² ; Omrani MD³ ; Kazcrouni F¹ ; Shanaki M¹ ; Ghaffarzadeh M¹ ; Pashaiefar H⁴ ; Rahimipour A¹

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1. Department of Medical Lab Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasiij, Iran
3. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Clinical Laboratory Published:2017

Abstract

Background: Recent reports have suggested that single-nucleotide polymorphisms (SNPs) in microRNA genes may contribute to individual susceptibility to coronary artery disease (CAD). The purpose of this study was to evaluate the association between rs3746444 in pre-miR-499 with CAD. Methods: We performed a case-control study including 288 CAD patients and 150 control subjects. DNA was extracted from blood samples and genotyped through the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Meta-analysis was performed under fixed effect and random effect models whenever appropriate. Results: We found that the GG genotype is significantly more frequent in CAD patients than controls (adjusted p = 0.010; OR = 1.99, 95%; CI: 1.18 - 3.38). Additionally, through a meta-analysis, we showed that miR-499- rs3746444 has a significant association with cardiovascular disease. Conclusions: Our results suggest that miR-499-rs3746444-GG is associated with CAD susceptibility and development.

2. Effects of Micro Rnas and Their Targets in Periodontal Diseases, Infectious Disorders - Drug Targets (2018)

3. Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art, Biomedicine and Pharmacotherapy (2019)

4. Comments On: “A Meta-Analysis of the Association Between Microrna-196A2 and Risk of Ischemic Stroke and Coronary Artery Disease in Asian Population”, Journal of Stroke and Cerebrovascular Diseases (2019)

5. Association of Microrna Gene Polymorphisms With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis, Journal of Research in Medical Sciences (2020)

6. The Potential for Circulating Micrornas in the Diagnosis of Myocardial Infarction: A Novel Approach to Disease Diagnosis and Treatment, Current Pharmaceutical Design (2016)

7. Association of Mir-149 (Rs2292832) Variant With the Risk of Coronary Artery Disease, Journal of Medical Biochemistry (2017)

8. Comments on “Association Between Mir-499 Rs3746444 Polymorphism and Coronary Heart Disease Susceptibility: An Evidence-Based Meta-Analysis of 5063 Cases and 4603 Controls”, Gene (2019)

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Style	Citing Format
MLA	Labbaf A, et al.. "The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study." Clinical Laboratory, vol. 63, no. 3, 2017, pp. 587-595.
APA	Labbaf A, Ghaedi I, Alipoor B, Omrani MD, Kazcrouni F, Shanaki M, Ghaffarzadeh M, Pashaiefar H, Rahimipour A (2017). The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study. Clinical Laboratory, 63(3), 587-595.
Chicago	Labbaf A, Ghaedi I, Alipoor B, Omrani MD, Kazcrouni F, Shanaki M, Ghaffarzadeh M, Pashaiefar H, Rahimipour A. "The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study." Clinical Laboratory 63, no. 3 (2017): 587-595.
Harvard	Labbaf A et al. (2017) 'The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study', Clinical Laboratory, 63(3), pp. 587-595.
Vancouver	Labbaf A, Ghaedi I, Alipoor B, Omrani MD, Kazcrouni F, Shanaki M, et al.. The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study. Clinical Laboratory. 2017;63(3):587-595.
BibTex	@article{ author = {Labbaf A and Ghaedi I and Alipoor B and Omrani MD and Kazcrouni F and Shanaki M and Ghaffarzadeh M and Pashaiefar H and Rahimipour A}, title = {The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study}, journal = {Clinical Laboratory}, volume = {63}, number = {3}, pages = {587-595}, year = {2017} }
RIS	TY - JOUR AU - Labbaf A AU - Ghaedi I AU - Alipoor B AU - Omrani MD AU - Kazcrouni F AU - Shanaki M AU - Ghaffarzadeh M AU - Pashaiefar H AU - Rahimipour A TI - The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study JO - Clinical Laboratory VL - 63 IS - 3 SP - 587 EP - 595 PY - 2017 ER -

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