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The Relationship Between C-Reactive Protein and Levels of Various Cytokines in Patients With Covid-19: A Systematic Review and Correlation Analysis Publisher



Seyedalinaghi S1 ; Karimi A2 ; Mirzapour P1 ; Afroughi F3, 4 ; Noroozi A3 ; Arjmand G5 ; Abshenas S6 ; Pashaei Z1 ; Tantuoyir MM2, 7 ; Dadras O1, 8 ; Qaderi K9 ; Saeidi S10 ; Dehghani S2 ; Shabanzadeh Pirsaraie A11 Show All Authors
Authors
  1. Seyedalinaghi S1
  2. Karimi A2
  3. Mirzapour P1
  4. Afroughi F3, 4
  5. Noroozi A3
  6. Arjmand G5
  7. Abshenas S6
  8. Pashaei Z1
  9. Tantuoyir MM2, 7
  10. Dadras O1, 8
  11. Qaderi K9
  12. Saeidi S10
  13. Dehghani S2
  14. Shabanzadeh Pirsaraie A11
  15. Mehraeen E12
  16. Afsahi AM13
Show Affiliations
Authors Affiliations
  1. 1. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Islamic Azad University, Tehran, Iran
  4. 4. Pars Hospital, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Biomedical Engineering Unit, University of Ghana Medical Center (UGMC), Accra, Ghana
  8. 8. Department of Global Public Health and Primary Care, Graduate School of Medicine, Bergen University, Bergen, Norway
  9. 9. Department of Midwifery, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran
  10. 10. Department of Nursing, Khalkhal University of Medical Sciences, Khalkhal, Iran
  11. 11. Islamic Azad University of Karaj Branch, Karaj, Iran
  12. 12. Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran
  13. 13. Department of Radiology, School of Medicine, University of California, San Diego (UCSD), San Diego, CA, United States

Source: Health Science Reports Published:2022


Abstract

Introduction: C-reactive protein (CRP) and cytokines levels could alter in patients with coronavirus disease (COVID-19) due to the inflammatory response caused by the virus. This analysis aimed to assess the relationship between the CRP levels and the levels of various cytokines in COVID-19 patients. Materials and Methods: We searched the databases of PubMed, Cochrane, and Web of Science for relevant articles on May 29th, 2021. Applying the inclusion/exclusion criteria, the retrieved records underwent two-phase screenings; first, a title/abstract screening process, and then, a full-text screening to find the eligible studies. Data for study variables were extracted, including the CRP levels and the levels of all reported cytokines. A strong and significant relationship between Interleukins and CRP was defined as: p ≤ 0.05, 0.7 ≤ r ≤ 1. Results: In this study, 103 studies were included for systematic review and correlation analysis. The aggregate mean and SD of study variables were calculated and reported. The correlation between Interleukins and CRP was measured using correlation coefficient (r). It appeared that interleukin (IL)-10 has a moderate and significant relationship with CRP (p ≤ 0.05, r = 0.472). IL-10 predicted almost 10% of CRP changes. Conclusion: This correlation analysis suggests IL-10 is moderately correlated with CRP levels in patients with COVID-19 infection. A better understanding of the pro-inflammatory markers could contribute to the implementation of therapeutic and preventive approaches. More prospective studies are suggested to explore the relationship between CRP and cytokines as potential markers for the early identification of COVID-19 progression and severity. © 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC.
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