A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19

A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19 Publisher

Dehghanbanadaki H^{1, 2} ; Aazami H^{3, 4} ; Shabani M⁵ ; Amighi D⁵ ; Seif F⁶ ; Dehnavi AZ⁵ ; Hajighadery A⁷ ; Nejad MMM⁷ ; Ghafouri M⁵ ; Hajizadeh N⁸ ; Abedin F⁵ ; Hajizadeh Z⁸ ; Heravi M⁹ ; Panahi P¹⁰ Show All Authors

Dehghanbanadaki H^{1, 2}
Aazami H^{3, 4}
Shabani M⁵
Amighi D⁵
Seif F⁶
Dehnavi AZ⁵
Hajighadery A⁷
Nejad MMM⁷
Ghafouri M⁵
Hajizadeh N⁸
Abedin F⁵
Hajizadeh Z⁸
Heravi M⁹
Panahi P¹⁰
Kabir A¹¹

Show Affiliations

1. Metabolomics and Genomics Research Center Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Immunology and Allergy, Academic Center for Education Culture and Research (ACECR), Tehran, Iran
7. Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran
8. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
9. School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
10. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
11. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Immunopathologia Persa Published:2022

Abstract

Introduction: Prominent prognostic parameters that reflect the severity of coronavirus disease 2019 (COVID-19) to adopt an appropriate therapeutic approach are not fully identified. This systematic review and meta-analysis aimed to explore the association between lymphocyte variation and disease severity in COVID-19 individuals. Methods: We searched Web of Science, Scopus, PubMed, EMBASE and WHO website to retrieve studies investigating lymphocyte subset counts in non-severe and severe cases of COVID-19. The pooled standardized mean difference (SMD) between two groups and the pooled average count of each lymphocyte subset were assessed by employing a random-effect model. Results: Thirty-nine investigations on 5087 participants, including 3578 non-severe patients and 1509 severe patients, were included. The pooled analysis showed that non-severe patients had higher total T lymphocytes (SMD = 1.01; 95% CI: 0.82, 1.20; I2 = 75.7%), T helper cells (SMD = 1.07; 95% CI: 0.85, 1.28; I2 = 85.4%), T cytotoxic cells (SMD = 1.07; 95% CI: 0.82, 1.32; I2 = 87.1%), B cells (SMD = 0.72; 95% CI: 0.45, 0.98; I2 = 79.7%), and natural killer cells (SMD = 0.65; 95% CI: 0.47, 0.84; I2 = 63.1%) than severe patients and the average count of the corresponding lymphocyte signatures in non-severe patients/severe patients were 878.88/448.40, 493.12/268.96, 311.91/158.91, 177.09/110.37, and 155.02/103.09 cells/μL, respectively. Conclusion: Lymphopenia may be a dilemma in COVID-19 management because over-activation of lymphocytes may lead to cytokine storm or acute respiratory distress syndrome (ARDS). In contrast, lymphopenia may increase SARS-CoV-2 amplification and COVID-19 severity. Therefore, novel therapies targeting lymphocyte proliferation or contraction may counterbalance lymphocyte counts in these patients. © 2022 The Authors.

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Style	Citing Format
MLA	Dehghanbanadaki H, et al.. "A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19." Immunopathologia Persa, vol. 8, no. 2, 2022, pp. -.
APA	Dehghanbanadaki H, Aazami H, Shabani M, Amighi D, Seif F, Dehnavi AZ, Hajighadery A, Nejad MMM, Ghafouri M, Hajizadeh N, Abedin F, Hajizadeh Z, Heravi M, Panahi P, Kabir A (2022). A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19. Immunopathologia Persa, 8(2), -.
Chicago	Dehghanbanadaki H, Aazami H, Shabani M, Amighi D, Seif F, Dehnavi AZ, Hajighadery A, et al.. "A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19." Immunopathologia Persa 8, no. 2 (2022): -.
Harvard	Dehghanbanadaki H et al. (2022) 'A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19', Immunopathologia Persa, 8(2), pp. -.
Vancouver	Dehghanbanadaki H, Aazami H, Shabani M, Amighi D, Seif F, Dehnavi AZ, et al.. A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19. Immunopathologia Persa. 2022;8(2):-.
BibTex	@article{ author = {Dehghanbanadaki H and Aazami H and Shabani M and Amighi D and Seif F and Dehnavi AZ and Hajighadery A and Nejad MMM and Ghafouri M and Hajizadeh N and Abedin F and Hajizadeh Z and Heravi M and Panahi P and Kabir A}, title = {A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19}, journal = {Immunopathologia Persa}, volume = {8}, number = {2}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Dehghanbanadaki H AU - Aazami H AU - Shabani M AU - Amighi D AU - Seif F AU - Dehnavi AZ AU - Hajighadery A AU - Nejad MMM AU - Ghafouri M AU - Hajizadeh N AU - Abedin F AU - Hajizadeh Z AU - Heravi M AU - Panahi P AU - Kabir A TI - A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19 JO - Immunopathologia Persa VL - 8 IS - 2 SP - EP - PY - 2022 ER -

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