The Applications of Anti-Cd20 Antibodies to Treat Various B Cells Disorders

The Applications of Anti-Cd20 Antibodies to Treat Various B Cells Disorders Publisher Pubmed

Payandeh Z¹ ; Bahrami AA² ; Hoseinpoor R² ; Mortazavi Y^{3, 7} ; Rajabibazl M^{4, 5} ; Rahimpour A⁵ ; Taromchi AH³ ; Khalil S⁶

Show Affiliations

1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Cancer Gene Therapy Research Center, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
7. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Biomedicine and Pharmacotherapy Published:2019

Abstract

B-lymphocyte antigen CD20 (called CD20) is known as an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells. CD20 is involved in the regulation of trans-membrane Ca 2+ conductance and also play critical roles in cell‐cycle progression during human B cell proliferation and activation. The appearance of monoclonal antibody (mAb) technology provided an effective field for targeted therapy in treatment of a variety of diseases such as cancer, and autoimmune diseases. Anti-CD20 is one of important antibodies which could be employed in treatment of several diseases. Increasing evidences revealed that efficacy of different anti-CD20 antibodies is implicated by their function. Hence, evaluation of anti-CD20 antibodies function could provide and introduce new anti-CD20 based therapies. In the present study, we summarized several applications of anti-CD20 antibodies in various immune related disorders including B-CLL (B-cell chronic lymphocytic leukemia), rheumatoid arthritis (RA), multiple sclerosis (MS) and melanoma. © 2018

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Style	Citing Format
MLA	Payandeh Z, et al.. "The Applications of Anti-Cd20 Antibodies to Treat Various B Cells Disorders." Biomedicine and Pharmacotherapy, vol. 109, no. , 2019, pp. 2415-2426.
APA	Payandeh Z, Bahrami AA, Hoseinpoor R, Mortazavi Y, Rajabibazl M, Rahimpour A, Taromchi AH, Khalil S (2019). The Applications of Anti-Cd20 Antibodies to Treat Various B Cells Disorders. Biomedicine and Pharmacotherapy, 109(), 2415-2426.
Chicago	Payandeh Z, Bahrami AA, Hoseinpoor R, Mortazavi Y, Rajabibazl M, Rahimpour A, Taromchi AH, Khalil S. "The Applications of Anti-Cd20 Antibodies to Treat Various B Cells Disorders." Biomedicine and Pharmacotherapy 109, no. (2019): 2415-2426.
Harvard	Payandeh Z et al. (2019) 'The Applications of Anti-Cd20 Antibodies to Treat Various B Cells Disorders', Biomedicine and Pharmacotherapy, 109(), pp. 2415-2426.
Vancouver	Payandeh Z, Bahrami AA, Hoseinpoor R, Mortazavi Y, Rajabibazl M, Rahimpour A, et al.. The Applications of Anti-Cd20 Antibodies to Treat Various B Cells Disorders. Biomedicine and Pharmacotherapy. 2019;109():2415-2426.
BibTex	@article{ author = {Payandeh Z and Bahrami AA and Hoseinpoor R and Mortazavi Y and Rajabibazl M and Rahimpour A and Taromchi AH and Khalil S}, title = {The Applications of Anti-Cd20 Antibodies to Treat Various B Cells Disorders}, journal = {Biomedicine and Pharmacotherapy}, volume = {109}, number = {}, pages = {2415-2426}, year = {2019} }
RIS	TY - JOUR AU - Payandeh Z AU - Bahrami AA AU - Hoseinpoor R AU - Mortazavi Y AU - Rajabibazl M AU - Rahimpour A AU - Taromchi AH AU - Khalil S TI - The Applications of Anti-Cd20 Antibodies to Treat Various B Cells Disorders JO - Biomedicine and Pharmacotherapy VL - 109 IS - SP - 2415 EP - 2426 PY - 2019 ER -

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