Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Rs16944 Snp in Il-1B and Risk of Polycystic Ovarian Syndrome Publisher



Salehgargari S1 ; Ghafourifard S2 ; Zandieh Z3 ; Ansaripour S4 ; Pouresmaeili F5 ; Vatannejad A6, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Feto-Maternal Unit, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Shahid Akbar Abadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran
  4. 4. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  5. 5. Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  7. 7. Student's Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Gene Reports Published:2019


Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine condition in females during the reproductive years. Several genetic factors have been shown to impact the normal ovulation and be involved in the pathogenesis of PCOS. Genes regulating immune responses are among these factors. In the current investigation, we genotyped a variant in Interleukin (IL)-1B gene (rs16944) in 270 patients with PCOS (including 154 infertile cases (PCOS-I) and 116 cases with history of recurrent abortion (PCOS-A)) and 112 healthy controls. There was no significant difference in frequencies of rs16944 alleles/genotypes between PCOS-I subjects and healthy controls. However, the G allele of the rs16944 SNP was less frequent among PCOS-A cases compared with controls (OR (95% CI) = 0.58 (0.4–0.84), P value = 0.004). The rs16944 SNP was associated with PCOS-A in co-dominant (GG vs. AA: OR (95% CI) = 0.37 (0.18–0.76), P value = 0.02), dominant (AG + GG vs. AA: OR (95% CI) = 0.51 (0.28–0.91), P value = 0.02) and recessive (GG vs. AG + AA: OR (95% CI) = 0.50 (0.27–0.92), P value = 0.02) models. Taken together, the mentioned SNP can be regarded as a risk locus for a certain type of PCOS in Iranian population. © 2019 Elsevier Inc.
Related Docs
1. Investigation of Adrenoceptor Genes (Β2 & Β3) in Women With Polycystic Ovary Syndrome, Tehran University Medical Journal (2018)
2. Carnitine and Chromium Co-Supplementation Affects Mental Health, Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome, Journal of Psychosomatic Obstetrics and Gynecology (2019)
3. Investigation Trp64arg Polymorphism of the Beta 3-Adrenergic Receptor Gene in Nonobese Women With Polycystic Ovarian Syndrome, International Journal of Reproductive BioMedicine (2020)
4. Inflammatory and Genomic Interactions Within Keratoconus Susceptible Patients: A Nationwide Registered Case–Control Study, Eye and Vision (2024)