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The Combined Effects of a Methacrylate Powder Dressing (Altrazeal Powder) and Photobiomodulation Therapy on the Healing of a Severe Diabetic Foot Ulcer in a Diabetic Patient: A Case Report Publisher



Derakhshan R1 ; Ahmadi H2 ; Bayat M2, 3, 4 ; Mehboudi L5 ; Pourhashemi E6 ; Amini A2 ; Vatandoust D2 ; Aghamiri S7 ; Asadi R8 ; Sabet B9
Authors
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Authors Affiliations
  1. 1. Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
  3. 3. Price Institute of Surgical Research, University of Louisville, Louisville, KY, United States
  4. 4. Noveratech LLC, Louisville, KY, United States
  5. 5. Department of Anesthesia, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
  6. 6. School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  7. 7. Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Paramedicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran

Source: Journal of Lasers in Medical Sciences Published:2022


Abstract

Weakened wound healing is a popular, severe complication of patients with diabetes which poses a risk for foot infection and amputation. Researchers have searched for new treatments for treating diabetic foot ulcers (DFUs) in recent years. In this case report, for the first time, we applied photobiomodulation therapy (PBMT) and Altrazeal powder together to treat a severe case of DFU in a 47-year-old woman who was suffering from type 1 diabetes. Along with the progress of combination therapy, we observed that the ulcer area was significantly reduced, and the wound healed within 16 weeks. Furthermore, dermatitis and purulent secretion were treated, and the pain was reduced. This reported case study indicated the beneficial effect of the combination of PBMT and Altrazeal powder for the healing of a severe DFU in a patient with type one diabetes. The combined application of PBMT plus Altrazeal powder demonstrated an additive effect. Further clinical trials in the clinical setting are suggested to validate the results further. Besides, more studies in preclinical models are suggested to find the mechanism of the action of combination therapy © 2022, Journal of Lasers in Medical Sciences.All Rights Reserved.
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