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Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds With a Multifunctional Wound Dressing Publisher Pubmed



Atashgah RB1, 2 ; Ghasemi A3 ; Raoufi M3, 4 ; Abdollahifar MA5 ; Zanganeh S6 ; Nejadnik H7 ; Abdollahi A2 ; Sharifi S8 ; Lea B1 ; Cuerva M9 ; Akbarzadeh M10 ; Alvarezlorenzo C11 ; Ostad SN2 ; Theus AS12 Show All Authors
Authors
  1. Atashgah RB1, 2
  2. Ghasemi A3
  3. Raoufi M3, 4
  4. Abdollahifar MA5
  5. Zanganeh S6
  6. Nejadnik H7
  7. Abdollahi A2
  8. Sharifi S8
  9. Lea B1
  10. Cuerva M9
  11. Akbarzadeh M10
  12. Alvarezlorenzo C11
  13. Ostad SN2
  14. Theus AS12
  15. Larock DL13
  16. Larock CN13
  17. Serpooshan V12, 14, 15
  18. Sarrafi R16
  19. Lee KB17
  20. Vali H18
  21. Schonherr H4
  22. Gould L19, 20
  23. Taboada P1
  24. Mahmoudi M8, 21, 22
Show Affiliations
Authors Affiliations
  1. 1. Colloids and Polymers Physics Group, Particle Physics Department, Faculty of Physics, Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain
  2. 2. Department of Pharmaceutical Biomaterials, Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14167-53955, Iran
  3. 3. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 13169-43551, Iran
  4. 4. Physical Chemistry i, Department of Chemistry and Biology, Research Center of Micro and Nanochemistry and Engineering (Cμ), University of Siegen, Siegen, 57076, Germany
  5. 5. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19395-4719, Iran
  6. 6. Department of Bioengineering, University of Massachusetts Dartmouth, Dartmouth, 02747, MA, United States
  7. 7. Department of Radiology, University of Pennsylvania, Philladelphia, 19104, PA, United States
  8. 8. Precision Health Program, Michigan State University, East Lansing, 48824, MI, United States
  9. 9. NANOMAG Group, Technological Research Institute (IIT), Physical Chemistry Department, University of Santiago de Compostela (USC), Santiago de Compostela, 15782, Spain
  10. 10. Sadra Wound, Ostomy and Osteomyelitis Specialist Center, Tehran, Iran
  11. 11. R+D Pharma Group, Pharmacology, Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain
  12. 12. Wallace H. Coulter Department of Biomedical Engineering, Emory University, School of Medicine, Georgia Institute of Technology, Atlanta, 30322, GA, United States
  13. 13. Department of Microbiology and Immunology, Emory Antibiotic Resistance Center, Emory University, School of Medicine, Atlanta, 30322, GA, United States
  14. 14. Department of Pediatrics, Emory University, School of Medicine, Atlanta, 30309, GA, United States
  15. 15. Children's Healthcare of Atlanta, Atlanta, 30322, GA, United States
  16. 16. SciDerm, Natick, MA, United States
  17. 17. Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, 08854, NJ, United States
  18. 18. Department of Anatomy and Cell Biology and Facility for Electron Microscopy Research, McGill University, Montreal, H3A 0C3, QC, Canada
  19. 19. Brown University, School of Medicine, Providence, 02903, RI, United States
  20. 20. South Shore Health System Center for Wound Healing, Weymouth, 02189, MA, United States
  21. 21. Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States
  22. 22. Mary Horrigan Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States

Source: Molecular Pharmaceutics Published:2021


Abstract

Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products. © 2021 American Chemical Society.
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