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Trim14 and Trim29 As Potential Tumor Markers for Breast Cancer Diagnosis; [14Trim و 29Trim به عنوان تومور مارکرهای بالقوه برای تشخیص ]



Roshanazadeh M1 ; Rashidi M1 ; Sanaei A1 ; Dariuni HA1 ; Razavi AE2 ; Adelipour M1
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Medical Basic Sciences Research Institution, Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Iran National Tumor Bank, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Breast Diseases Published:2024

Abstract

Introduction: Various members of the Tripartite-motif protein family contribute to different types of cancer, although the role of these factors in breast cancer is unclear. TRIM14 and TRIM29 have been reported to be overexpressed and play oncogenic roles in specific cancers. Methods: A total of 40 pairs of tumor tissues and adjacent normal tissues of breast cancer patients were obtained. Relative gene expression of TRIM14 and TRIM29 were determined through quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) using specific primers. Results: TRIM14 and TRIM29 were both overexpressed in breast tumor samples. The expression of TRIM14 was associated with tumor size, stage, and invasiveness. Nonetheless, no association was found between TRIM14 and the grade of the tumor. Also, TRIM29 gene expression was positively correlated with tumor size, stage, grade, and invasiveness. No correlation was found between the expression of TRIM14 and TRIM29. Conclusion: Based on our results, we propose TRIM14 and TRIM29 as potential tumor markers in breast cancer. Copyright © 2024 Roshanazadeh1 et al. Published by Breast Cancer Recearch Center, ACECR.
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