Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Review Study About the Effect of Chitosan Nanocarrier on Improving the Efficacy of Amphotericin B in the Treatment of Leishmania From 2010 to 2020 Publisher Pubmed



Mehrizi TZ1 ; Rezayat SM2 ; Ardestani MS3 ; Shahmabadi HE4 ; Ramezani A5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  2. 2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  5. 5. Department of Clinical Research, Pasteur Institute of Iran, Tehran, Iran

Source: Current Drug Delivery Published:2021


Abstract

In the present review study, the published articles from 2010-2020 that evaluated the effect of chitosan nanocarrier on the efficacy of amphotericin B (AmB) in the treatment of leishmaniasis, have been considered. Leishmania is a parasitic tropical disease in the world and is treated with AmB as one of the main therapeutic agents. However, the clinical application of AmB is limited due to its toxicity and insolubility issues. Using nanoparticles and, in particular, chitosan, nanocarrier seems a promising approach to overcome these problems. Therefore, various doses of AmB have been loaded in chitosan nanoparticles in different studies and the results of these studies demonstrated that by increasing the drug loading efficiency and decreasing the toxicity, the potency of the nanoformulation to inhibit and to kill the parasite is increased. In this regard, the results of a study performed in 2018, demonstrated that chitosan nanoparticles with the higher dose of drug loading were the most effective formulation to inhibit and kill the parasite. Thus, chitosan nanocarrier can consider as an appropriate candidate in the future to inhibit and kill the Leishmania parasite without causing side effects © 2021 Bentham Science Publishers
Related Docs
View other Related Docs
1. Comparative Analysis Between Four Model Nanoformulations of Amphotericin B-Chitosan, Amphotericin B-Dendrimer, Betulinic Acid-Chitosan and Betulinic Acid-Dendrimer for Treatment of Leishmania Major: Real-Time Pcr Assay Plus, International Journal of Nanomedicine (2019)
2. Advances in Nanotechnology for Improving the Targeted Delivery and Activity of Amphotericin B (2011–2023): A Systematic Review, Nanotoxicology (2024)
3. Novel Nano-Sized Chitosan Amphotericin B Formulation With Considerable Improvement Against Leishmania Major, Nanomedicine (2018)
4. Novel Nanosized Chitosan-Betulinic Acid Against Resistant Leishmania Major and First Clinical Observation of Such Parasite in Kidney, Scientific Reports (2018)
5. In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis, Archives of Clinical Infectious Diseases (2018)
6. Reduction Toxicity of Amphotericin B Through Loading Into a Novel Nanoformulation of Anionic Linear Globular Dendrimer for Improve Treatment of Leishmania Major, Journal of Materials Science: Materials in Medicine (2018)
7. A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer, Journal of Nanostructures (2021)
8. A Review of the Use of Metallic Nanoparticles As a Novel Approach for Overcoming the Stability Challenges of Blood Products: A Narrative Review From 2011-2021, Current Drug Delivery (2023)
Experts (# of related papers)
View all Related Experts
Mehdi Shafee Ardestani (13)
Mohammad Vodjgani (2)
Other Related Docs
9. Pegylation, a Successful Strategy to Address the Storage and Instability Problems of Blood Products: Review 2011-2021, Current Pharmaceutical Biotechnology (2024)
10. A Review Study of the Use of Modified Chitosan As a New Approach to Increase the Preservation of Blood Products (Erythrocytes, Platelets, and Plasma Products): 2010-2022, Nanomedicine Journal (2023)
11. Chitosan Nanoparticles Improve the Effectivity of Miltefosine Against Acanthamoeba, PLoS Neglected Tropical Diseases (2024)
12. Application of Nano-Based Systems for Drug Delivery and Targeting: A Review, Journal of Nanoparticle Research (2020)
13. Chitosan-Based Biocompatible Dressing for Treatment of Recalcitrant Lesions of Cutaneous Leishmaniasis: A Pilot Clinical Study, Indian Journal of Dermatology# Venereology and Leprology (2019)
14. The Latest Findings of Gamma Irradiation of Blood Products to Prevent Transfusion-Associated Graft-Versus-Host Disease (Ta-Gvhd) in Cancer Patients: A Systematic Review, Iranian Journal of Nuclear Medicine (2024)
15. A Review Study on the Application of Polymeric-Based Nanoparticles As a Novel Approach for Enhancing the Stability of Albumins, Nanomedicine Journal (2022)
16. Effective Materials of Medicinal Plants for Leishmania Treatment in Vivo Environment, Journal of Medicinal Plants (2020)
17. The Introduction of Dendrimers As a New Approach to Improve the Performance and Quality of Various Blood Products (Platelets, Plasma and Erythrocytes): A 2010-2022 Review Study, Current Nanoscience (2023)
18. Unravelling Toxoplasma Treatment: Conventional Drugs Toward Nanomedicine, World Journal of Microbiology and Biotechnology (2021)
19. Latest Findings on the Effects of Gold Nanoparticles on the Storage Quality of Blood Products (2011-2022) - a Narrative Review, Current Drug Delivery (2024)
20. Relationship of Leishmania Rna Virus (Lrv) and Treatment Failure in Clinical Isolates of Leishmania Major, BMC Research Notes (2020)
21. Novel Strategies and Pharmaceutical Agents for the Treatment of Leish-Maniasis: A Review, Anti-Infective Agents (2020)
22. Niosomal Formulation of Amphotericin B Alone and in Combination With Glucantime: In Vitro and in Vivo Leishmanicidal Effects, Biomedicine and Pharmacotherapy (2019)
23. The Synthesis, Application and Therapeutic Perspectives of Medicinal Plants-Based Solid Lipid Nanoparticles: A Comprehensive Review, Advances in Traditional Medicine (2025)
24. Improvement of the Solubility Amphotericin B Using Olive Oil Nanoemulsion Coated With Chitosan for More Effective Treatment of Zoonotic Cutaneous Leishmaniasis, Iranian Journal of Pharmaceutical Research (2021)
25. Stimuli-Responsive Chitosan-Based Nanocarriers for Drug Delivery in Wound Dressing Applications: A Review, Carbohydrate Polymer Technologies and Applications (2024)
26. Chitosan Nanoparticles, As Biological Macromolecule-Based Drug Delivery Systems to Improve the Healing Potential of Artificial Neural Guidance Channels: A Review, International Journal of Biological Macromolecules (2022)