Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Expression Profile of Mirnas in Urine Samples of Bladder Cancer Patients Publisher Pubmed



Nekoohesh L1 ; Modarressi MH2 ; Mowla SJ3 ; Sadroddiny E1 ; Etemadian M4 ; Afsharpad M5 ; Zolfaghari F6 ; Barzegari M6 ; Saffari M6 ; Oskooei VK6 ; Motevaseli E2 ; Ghafourifard S7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Biological Sciences, Department of Genetics, Tarbiat Modares University, Tehran, Iran
  4. 4. Department of Urology, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Cancer Control Research Center, Cancer Control Foundation, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Biomarkers in Medicine Published:2018


Abstract

Aim: miRNAs have been suggested as biomarkers for bladder cancer. We aimed to find a diagnostic panel of miRNAs based on differential expression of miRNAs in urine specimens of patient with bladder cancer compared with control group. Methods: miR-141, miR-10b, miR-34b and miR-103 were selected to assess their expression in urine samples of 66 bladder cancer patients and 53 matched controls using quantitative real time PCR. Results: miR-10b and miR-34b were upregulated in cases compared with controls. The combination of four miRNAs showed a sensitivity of 75% and specificity of 63.5% with a diagnostic power of 72%. Conclusion: Certain miRNAs can be used as biomarkers for early diagnosis of bladder cancer. © 2018 2018 Future Medicine Ltd.
Related Docs
1. Pre-Analytical Practices in the Molecular Diagnostic Tests, a Concise Review, Iranian Journal of Pathology (2020)
2. An Innovative Paradigm of Methods in Micrornas Detection: Highlighting Dnazymes, the Illuminators, Biosensors and Bioelectronics (2018)
3. Direct and Indirect Medical Costs of Bladder Cancer in Iran, Cost Effectiveness and Resource Allocation (2023)
4. Bladder Cancer Incidence in Iran: Results of the Iranian National Population-Based Cancer Registry From 2014 to 2016, Urology Journal (2022)
5. Epidemiology and Hospitalization Cost of Bladder Cancer in Kerman Province, Southeastern Iran, Iranian Journal of Public Health (2018)
6. Tert Promoter Mutations As Simple and Non-Invasive Urinary Biomarkers for the Detection of Urothelial Bladder Cancer in a High-Risk Region, International Journal of Molecular Sciences (2022)
7. Liquid Biopsy in Bladder Tumors, Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)
8. The Association of Mir-Let 7B and Mir-548 With Pten in Prostate Cancer, Urology Journal (2019)
Experts (# of related papers)
View all Related Experts
Kazem Zendehdel (3)
Rajabali Daroudi (2)