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Controlled Release of Doxorubicin From Electrospun Peo/Chitosan/Graphene Oxide Nanocomposite Nanofibrous Scaffolds Publisher Pubmed



Ardeshirzadeh B1 ; Anaraki NA2 ; Irani M3, 4 ; Rad LR4 ; Shamshiri S2
Authors
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Authors Affiliations
  1. 1. Faculty of Chemical Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor, 81310, Malaysia
  2. 2. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
  3. 3. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Hafez Ave., P.O. Box 15875-4413, Tehran, Iran
  4. 4. Medical Biomaterials Research Center (MBRC), Tehran University of Medical Science, Tehran, Iran

Source: Materials Science and Engineering C Published:2015


Abstract

Polyethylene oxide (PEO)/chitosan (CS)/graphene oxide (GO) electrospun nanofibrous scaffolds were successfully developed via electrospinning process for controlled release of doxorubicin (DOX). The SEM analysis of nanofibrous scaffolds with different contents of GO (0.1, 0.2, 0.5 and 0.7 wt.%) indicated that the minimum diameter of nanofibers was found to be 85 nm for PEO/CS/GO 0.5% nanofibers. The π-π stacking interaction between DOX and GO with fine pores of nanofibrous scaffolds exhibited higher drug loading (98%) and controlled release of the DOX loaded PEO/CS/GO nanofibers. The results of DOX release from nanofibrous scaffolds at pH 5.3 and 7.4 indicated strong pH dependence. The hydrogen bonding interaction between GO and DOX could be unstable under acidic conditions which resulted in faster drug release rate in pH 5.3. The cell viability results indicated that DOX loaded PEO/CS/GO/DOX nanofibrous scaffold could be used as an alternative source of DOX compared with free DOX to avoid the side effects of free DOX. Thus, the prepared nanofibrous scaffold offers as a novel formulation for treatment of lung cancer. ©2014 Elsevier B.V. All rights reserved.
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