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Evaluation of Association Between the Serum Levels of Mmp-9 and Mmp-9/Timps With Soluble Forms of Selectins and Itching Induced by Sulfur Mustard



Askari N1 ; Ghazanfari T2 ; Naghizadeh MM2 ; Moin A2 ; Khamesipour A3 ; Pourfarzam S2 ; Hassan ZM4
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Authors Affiliations
  1. 1. Dept. of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
  2. 2. Immunoregulation Research Center, Shahed University, Tehran, Iran
  3. 3. Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Dept. of Immunology, Tarbiat Moddares University, Tehran, Iran

Source: Iranian Journal of Pathology Published:2017

Abstract

Background & objective: Pruritus is the most frequent chronic dermal complication of sulfur mustard (SM), which negatively influences the quality of life. Exact pathophysiology of SM-induced itching is unknown. The current study aimed at evaluating the possible association between SM-induced itching and the serum levels of matrix metalloproteinase (MMP)-9 and their endogenous inhibitors, and serum levels of soluble forms of selectins (sL-, sP-, and sE-selectins) as adhesion molecules involved in the development of different inflammatory reactions. Methods: Serum levels of MMP-9, MMP-9/ tissue inhibitors of metalloproteinases (TIMPs), and selectins were measured by the enzyme-linked immunosorbent assay (ELISA), and compared between the groups (n=368) with and without itching, and matched control groups (n=126). Results: Serum levels of MMP-9 were significantly higher in the SM exposed group with itching, compared with that of the group without itching (medians: 894 and 624 pg/mL respectively; P-value =0.034). There was no relationship between the serum levels of MMP-9/TIMP-1, MMP-9/TIMP-2, MMP-9/TIMP-4, and itching in the patients exposed to SM. Median serum levels of sE- and sL-selectins in the exposed group with itching were higher than those of the exposed group without itching. These differences were statistically insignificant (P-values =0.084 and 0.095, respectively). Conclusion: According to the results of the current study, the increased serum levels of MMP-9 and selectins 20 years after exposure may play role in the pathogenesis and persistence of SM-induced itching in the exposed individuals. © 2017, IRANIAN JOURNAL OF PATHOLOGY.
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