New Antiprotozoal Sesquiterpene Derivatives From Dorema Glabrum Fisch & C.A.Mey

New Antiprotozoal Sesquiterpene Derivatives From Dorema Glabrum Fisch & C.A.Mey Publisher Pubmed

Delnavazi MR¹ ; Ebrahimi SN² ; Hadjiakhoondi A¹ ; Yassa N¹

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1. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C, Evin, Tehran, Iran

Source: Fitoterapia Published:2023

Abstract

Seven undescribed sesquiterpene derivatives, Azerins A-G (3–6, 8, 14 and 15), three known sesquiterpene phenols, kopetdaghin A (1), kopetdaghin B (2) and latisectin (7), together with five known sesquiterpene coumarins (9–13), were isolated from the roots of Dorema glabrum. The structures were elucidated by comprehensive 1D- and 2D-NMR spectral analysis as well as HR-ESI-MS. Compounds were assessed for their in vitro antiprotozoal activity against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum. Cytotoxic potentials of the compounds were also tested on L6 rat skeletal myoblasts. Azerin G (15) showed a potent preferential growth inhibitory activity against T. b. rhodesiense with IC50 value of 0.01 μM and selectivity index of 329. Compounds 1, 4, 7 and 8 were also found as the most active compounds with selective growth inhibitory effects toward P. falciparum with selectivity indices ranging from 11.6 to 16.7 (IC50: 1.8–24.6 μM). © 2023 Elsevier B.V.

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Style	Citing Format
MLA	Delnavazi MR, et al.. "New Antiprotozoal Sesquiterpene Derivatives From Dorema Glabrum Fisch & C.A.Mey." Fitoterapia, vol. 168, no. , 2023, pp. -.
APA	Delnavazi MR, Ebrahimi SN, Hadjiakhoondi A, Yassa N (2023). New Antiprotozoal Sesquiterpene Derivatives From Dorema Glabrum Fisch & C.A.Mey. Fitoterapia, 168(), -.
Chicago	Delnavazi MR, Ebrahimi SN, Hadjiakhoondi A, Yassa N. "New Antiprotozoal Sesquiterpene Derivatives From Dorema Glabrum Fisch & C.A.Mey." Fitoterapia 168, no. (2023): -.
Harvard	Delnavazi MR et al. (2023) 'New Antiprotozoal Sesquiterpene Derivatives From Dorema Glabrum Fisch & C.A.Mey', Fitoterapia, 168(), pp. -.
Vancouver	Delnavazi MR, Ebrahimi SN, Hadjiakhoondi A, Yassa N. New Antiprotozoal Sesquiterpene Derivatives From Dorema Glabrum Fisch & C.A.Mey. Fitoterapia. 2023;168():-.
BibTex	@article{ author = {Delnavazi MR and Ebrahimi SN and Hadjiakhoondi A and Yassa N}, title = {New Antiprotozoal Sesquiterpene Derivatives From Dorema Glabrum Fisch & C.A.Mey}, journal = {Fitoterapia}, volume = {168}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Delnavazi MR AU - Ebrahimi SN AU - Hadjiakhoondi A AU - Yassa N TI - New Antiprotozoal Sesquiterpene Derivatives From Dorema Glabrum Fisch & C.A.Mey JO - Fitoterapia VL - 168 IS - SP - EP - PY - 2023 ER -

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