Human Organs-On-Chips: A Review of the State-Of-The-Art, Current Prospects, and Future Challenges

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Human Organs-On-Chips: A Review of the State-Of-The-Art, Current Prospects, and Future Challenges Publisher Pubmed

Zarrintaj P¹ ; Saeb MR² ; Stadler FJ³ ; Yazdi MK⁴ ; Nezhad MN⁵ ; Mohebbi S⁶ ; Seidi F⁷ ; Ganjali MR^{4, 8} ; Mozafari M⁹

Source: Advanced Biology Published:2022

Abstract

New emerging technologies, remarkably miniaturized 3D organ models and microfluidics, enable simulation of the real in vitro microenvironment ex vivo more closely. There are many fascinating features of innovative organ-on-a-chip (OOC) technology, including the possibility of integrating semipermeable and/or stretchable membranes, creating continuous perfusion of fluids into microchannels and chambers (while maintaining laminar flow regime), embedding microdevices like microsensors, microstimulators, micro heaters, or different cell lines, along with other 3D cell culture technologies. OOC systems are designed to imitate the structure and function of human organs, ranging from breathing lungs to beating hearts. This technology is expected to be able to revolutionize cell biology studies, personalized precision medicine, drug development process, and cancer diagnosis/treatment. OOC systems can significantly reduce the cost associated with tedious drug development processes and the risk of adverse drug reactions in the body, which makes drug screening more effective. The review mainly focus on presenting an overview of the several previously developed OOC systems accompanied by subjects relevant to pharmacy-, cancer-, and placenta-on-a-chip. The challenging issues and opportunities related to these systems are discussed, along with a future perspective for this technology. © 2021 Wiley-VCH GmbH

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Style	Citing Format
MLA	Zarrintaj P, et al.. "Human Organs-On-Chips: A Review of the State-Of-The-Art, Current Prospects, and Future Challenges." Advanced Biology, vol. 6, no. 1, 2022, pp. -.
APA	Zarrintaj P, Saeb MR, Stadler FJ, Yazdi MK, Nezhad MN, Mohebbi S, Seidi F, Ganjali MR, Mozafari M (2022). Human Organs-On-Chips: A Review of the State-Of-The-Art, Current Prospects, and Future Challenges. Advanced Biology, 6(1), -.
Chicago	Zarrintaj P, Saeb MR, Stadler FJ, Yazdi MK, Nezhad MN, Mohebbi S, Seidi F, Ganjali MR, Mozafari M. "Human Organs-On-Chips: A Review of the State-Of-The-Art, Current Prospects, and Future Challenges." Advanced Biology 6, no. 1 (2022): -.
Harvard	Zarrintaj P et al. (2022) 'Human Organs-On-Chips: A Review of the State-Of-The-Art, Current Prospects, and Future Challenges', Advanced Biology, 6(1), pp. -.
Vancouver	Zarrintaj P, Saeb MR, Stadler FJ, Yazdi MK, Nezhad MN, Mohebbi S, et al.. Human Organs-On-Chips: A Review of the State-Of-The-Art, Current Prospects, and Future Challenges. Advanced Biology. 2022;6(1):-.
BibTex	@article{ author = {Zarrintaj P and Saeb MR and Stadler FJ and Yazdi MK and Nezhad MN and Mohebbi S and Seidi F and Ganjali MR and Mozafari M}, title = {Human Organs-On-Chips: A Review of the State-Of-The-Art, Current Prospects, and Future Challenges}, journal = {Advanced Biology}, volume = {6}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Zarrintaj P AU - Saeb MR AU - Stadler FJ AU - Yazdi MK AU - Nezhad MN AU - Mohebbi S AU - Seidi F AU - Ganjali MR AU - Mozafari M TI - Human Organs-On-Chips: A Review of the State-Of-The-Art, Current Prospects, and Future Challenges JO - Advanced Biology VL - 6 IS - 1 SP - EP - PY - 2022 ER -

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