Dual Blockage of Both Pd-L1 and Cd47 Enhances the Therapeutic Effect of Oxaliplatin and Folfox in Ct-26 Mice Tumor Model

Dual Blockage of Both Pd-L1 and Cd47 Enhances the Therapeutic Effect of Oxaliplatin and Folfox in Ct-26 Mice Tumor Model Publisher Pubmed

Alimohammadi R¹ ; Mahmoodi Chalbatani G² ; Alimohammadi M³ ; Ghaffarinazari H⁴ ; Rahimi A⁵ ; Mortaz E¹ ; Mossafa N¹ ; Boon L⁶ ; Jalali SA¹

Show Affiliations

1. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 198571-7443, Iran
2. Tumor Immunotherapy and Microenvironment (TIME) Group, Department of Oncology, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg
3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Immunology, Faculty of Medical Sciences, Mashhad University of Medical Science, Mashhad, Iran
5. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
6. JJP Biologics, Warsaw, Poland

Source: Scientific Reports Published:2023

Abstract

Colorectal cancer is a poorly immunogenic. Such property can be reverted by using ICD. However, ICD inducers can also induce the expression of inhibitory checkpoint receptors CD47 and PD-L1 on tumor cells, making CRC tumors resistant to mainly CD8 T cell killing and macrophage-mediated phagocytosis. In this study, we examined the therapeutic effect of Oxaliplatin and FOLFOX regimen in combination with blocking antibodies against CD47 and PD-L1. FOLFOX and Oxaliplatin treatment lead to an increase in CD47 and PD-L1 expression on CT-26 cells invitro and invivo. Combining blocking antibodies against CD47 and PD-L1 with FOLFOX leads to a significant increase in survival and a decrease in tumor size. This triple combining regimen also leads to a significant decrease in Treg and MDSC and a significant increase in CD8 + INF-γ + lymphocytes and M1/M2 macrophage ratio in the tumor microenvironment. Our study showed triple combining therapy with FOLFOX, CD47 and PD-L1 is an effective treatment regimen in CT-26 mice tumor model and may consider as a potential to translate to the clinic. © 2023, The Author(s).

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Style	Citing Format
MLA	Alimohammadi R, et al.. "Dual Blockage of Both Pd-L1 and Cd47 Enhances the Therapeutic Effect of Oxaliplatin and Folfox in Ct-26 Mice Tumor Model." Scientific Reports, vol. 13, no. 1, 2023, pp. -.
APA	Alimohammadi R, Mahmoodi Chalbatani G, Alimohammadi M, Ghaffarinazari H, Rahimi A, Mortaz E, Mossafa N, Boon L, Jalali SA (2023). Dual Blockage of Both Pd-L1 and Cd47 Enhances the Therapeutic Effect of Oxaliplatin and Folfox in Ct-26 Mice Tumor Model. Scientific Reports, 13(1), -.
Chicago	Alimohammadi R, Mahmoodi Chalbatani G, Alimohammadi M, Ghaffarinazari H, Rahimi A, Mortaz E, Mossafa N, Boon L, Jalali SA. "Dual Blockage of Both Pd-L1 and Cd47 Enhances the Therapeutic Effect of Oxaliplatin and Folfox in Ct-26 Mice Tumor Model." Scientific Reports 13, no. 1 (2023): -.
Harvard	Alimohammadi R et al. (2023) 'Dual Blockage of Both Pd-L1 and Cd47 Enhances the Therapeutic Effect of Oxaliplatin and Folfox in Ct-26 Mice Tumor Model', Scientific Reports, 13(1), pp. -.
Vancouver	Alimohammadi R, Mahmoodi Chalbatani G, Alimohammadi M, Ghaffarinazari H, Rahimi A, Mortaz E, et al.. Dual Blockage of Both Pd-L1 and Cd47 Enhances the Therapeutic Effect of Oxaliplatin and Folfox in Ct-26 Mice Tumor Model. Scientific Reports. 2023;13(1):-.
BibTex	@article{ author = {Alimohammadi R and Mahmoodi Chalbatani G and Alimohammadi M and Ghaffarinazari H and Rahimi A and Mortaz E and Mossafa N and Boon L and Jalali SA}, title = {Dual Blockage of Both Pd-L1 and Cd47 Enhances the Therapeutic Effect of Oxaliplatin and Folfox in Ct-26 Mice Tumor Model}, journal = {Scientific Reports}, volume = {13}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Alimohammadi R AU - Mahmoodi Chalbatani G AU - Alimohammadi M AU - Ghaffarinazari H AU - Rahimi A AU - Mortaz E AU - Mossafa N AU - Boon L AU - Jalali SA TI - Dual Blockage of Both Pd-L1 and Cd47 Enhances the Therapeutic Effect of Oxaliplatin and Folfox in Ct-26 Mice Tumor Model JO - Scientific Reports VL - 13 IS - 1 SP - EP - PY - 2023 ER -

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